Noteworthy News Articles on Mental Health Topics, March 1-21, 2000

 

New Study Reveals Anti-Depressants Alter Personality
Reuters New Service, 3/1/2000

Antidepressants may be able to change a person's personality, even in people who are not depressed. Dr. Victor Reus and colleagues at the University of California San Francisco said a small group of normal, non-depressed people who took Paxil, one of a new class of antidepressants called SSRIs, became more easygoing and cooperative.
"Different aspects of normal personality may be altered by psychopharmaceuticals that act on distinct nerve pathways in the brain," Reus said in a statement.

Better Teamwork Found
His team tested 23 mentally healthy men and women. They took paroxetine for a month, and filled out personality questionnaires before, during and after. After just a week on the drug, they scored lower on tests measuring hostility and showed more cooperative behavior in puzzle-solving tests. "People did seem to be…more likely to give suggestions and less likely to be assertive and directive," Reus said in a telephone interview. But he agreed that some people might not think that was an improvement. "As to whether that's good or bad I would refrain from putting any moral judgment." A matched group of volunteers who took a dummy pill showed no changes.

First of its Kind Study
"This is the first controlled study of the effects of a drug on a component of personality in people who are not mentally ill," Reus, whose findings are published in the American Journal of Psychiatry, said. "The result raises the issue of cosmetic psycho-pharmacology," Reus added—the idea of using psychiatric drugs for non-medical effects.
"The purpose of our doing the study is not to advocate usage like this," he stressed. He said some people felt such antidepressants were inappropriately used, or that if people were not clinically depressed the drugs would have no effect.

Question of Use
"I think what studies like this would suggest is that there really is a biologic effect there even in normal individuals," he said. "Whether it is useful or appropriate to use drugs in that manner is a different issue. In fact, people do this every day with drugs like nicotine or caffeine so it's not a radical phenomenon." Studies have shown that people with psychiatric disorders marked by hostility and aggression have low levels of serotonin. This important neurotransmitter, or message-carrying chemical, is linked with mood. Monkey studies have also linked serotonin with sociability.

Side-Effects Noted
There were side-effects—notably sleepiness at work, Reus's team reported. "For example, SSRI-treated volunteers' responses to the question 'What did you experience during the experiment' ranged from 'I used to think about good and bad but now I don't; I'm in a good mood,' to 'The side-effects were intense at first but then tapered off'," they wrote. Some people also complained of lowered sex drive or trouble achieving orgasm. SSRIs, or specific serotonin reuptake inhibitors, stop the reabsorption of serotonin, making it available in the body for longer. Paxil, also sold as Seroxat, is marketed by Anglo-American drugs group SmithKline Beecham Plc. The best-selling drug is licensed from Danish drugs group Novo Nordisk, which markets it in Scandinavia. Reus said other SSRI's such as fluoxetine, sold by Lilly under the name Prozac, would probably have similar effects.

Women's Depression Stems from Lifestyle Choices, Researchers Now Find
Julia McNamee Neenan, USA Today- 03/03/2000

Marsha knows she needs to exercise to keep her depression at bay. The 36-year-old West Palm Beach, Fla., psychologist works half-time and spends the rest of her week keeping house, running errands and caring for her 2-year-old twins while her husband works at a new job, often until 11 at night.   If she doesn't jog regularly, Marsha says, the depression from the stress of all that juggling would drag her into "a very blue day, bad, tearful, hopeless." What Marsha describes is not unusual in women's lives: Women are two to three times as likely as men to suffer from depression, according to the American Psychological Association. Yet only about one-fifth will get the treatment they need. And the National Institute of Mental Health estimates that more than 12 percent of all women suffer from depression each year, compared with 7 percent of men.
    That women suffer from depression is not news. But the underlying reasons for it are beginning to surface in a direction that may surprise many. For years, researchers blamed sex hormones for women's depression. The common phrases were "menopausal" or "premenstrual." Indeed, estrogen is still a factor in some areas of depression, according to Dr. Elizabeth Young, who runs a mood disorder clinic in Ann Arbor, Michigan. But hormone regulation doesn't account for much of the picture. Instead, researchers are beginning to focus on the quality of women's lives and the choices they make. In a recent article in the Journal of Personality and Social Psychology," Susan Nolen-Hoeksema, a national expert on women and depression, described a cycle of three factors that synergistically feed on one another to create symptoms of depression in women.

Stress is one culprit
The cycle starts with stress. "Women face a number of situations in their lives that make them feel out of control and helpless," says Nolen-Hoeksema, who is a professor at the University of Michigan. "Even when there are things they can do, they feel so out of control and helpless that they don't do what they can." It's no surprise to most women that their lives are stressful. Many, like Marsha the psychologist, wear many hats in their households. And few are willing to speak on the record if they are suffering any kind of depression. Both Martha and Amanda, a 33-year-old North Carolina government employee, didn't want their real names used so that those closest to them wouldn't recognize their stories. Amanda was working the same number of hours each day as her husband, but at one-fourth the pay. "I felt like I was inferior," she recalls. At the end of the work day, it was her job to clean the house, prepare for company, care for pets and run errands, like dropping off her husband's clothes at the cleaners. There wasn't enough time in the day for her to successfully complete her obligations. And so, she says, "I felt like a failure." The second part of the cycle, called "loss of mastery," is the sense many women have that they have no control over their lives. For some, like Amanda, it's a vague awareness that society has parceled out power, and women are on the short end. For others, like Marsha, it's the day-to-day knowledge that your life is subject to the whims of everyone from your boss to your babies. Marsha chose to work long hours at home alone while her husband pursued a new career. And as happy as she was to be home with her twins, she still felt isolated from friends, from the satisfactions of a professional life unencumbered by other responsibilities, and by the powerlessness of motherhood. "It's really hard," she says, and "it's really boring."
    Add to all this the third part of the cycle -- the fatal habit many women have of rumination. Unlike men, women tend not to take action, not to distract themselves. Instead, they dwell on their problems, sometimes endlessly, which only heightens their sense of despair and powerlessness, Nolen-Hoksema says. "I would have this feeling of 'I'm not good enough,'" Amanda recalls. "I'd think, 'This man obviously doesn't love me. What's the matter with me? I can't do better than this.' I'd feel really boxed in." And that, says Nolen-Hoeksema, is typical of how many women describe their blues. "You don't feel as though you're happy -- ever. You have no motivation. It's not 'I feel sad,' it's, 'I just don't feel anything anymore.' "

The need to take action
Twenty years ago, most psychologists would have talked a woman through her past, to determine the roots of her depression -- and probably add to her natural tendency to ruminate, says University of Massachusetts psychologist Bonnie Strickland. That's less common now, she says. Today, psychologists may recommend an anti-depressant to start with, simply to pull the woman out of her torpor so she can function and begin to make changes. And change is the key, says Eva Stubits, a clinical psychologist who directs Houston Psychological Associates in Texas. Psychologists try to help women sense that they can change their circumstances, Stubits says. Women can be shown some of the unhealthy ways they've been perceiving their lives -- that they've been too exclusively the caretaking members of the family. Often, Strickland says, that helps them to understand their relationships better, "to think about what are sources of happiness and pleasure." Concrete activities like exercise, reading, taking a class, meditation, or talking to a friend are all recommended steps to well-being. The goal, Nolen-Hoeksema says, is to break the cycle of despair. Women need to establish the sense that they can change their lives in positive ways, or, as Nolen-Hoeksema puts it, opt for "action and taking control." That's just what Marsha did, settling on the regular exercise regime that keeps her healthy and happy -- and that "general veil of grayness" at arm's length. Amanda hit upon an even more sweeping solution to her depression. With the help of "a lot of expensive therapy," she worked through her insecurities and along the way wound up ending her marriage. And, like Marsha, she now eats lots of healthful foods and gets plenty of exercise. "It really makes a big difference," she says simply.


Web Research Transforms Visit to the Doctor
Gina Kolata, New York Times Magazine, 3/6/2000

Victoria Schlesinger had a puzzling rash on her face, so she visited her doctor to ask what it was. The doctor told her she might have lupus, but declined to elaborate. "She said, 'Let's not talk about it until we know,'" Ms. Schlesinger said, a remark that only served to terrify her. "I walked out of there thinking, 'This can't be good.'" Ms. Schlesinger, 31, the chief counsel for the Teligent communications company in Vienna, Va., had never heard of lupus and was too intimidated to press her doctor for more information. But, like more and more patients in recent years, she also knew she had another resource. She went to her computer, typed in "lupus" and clicked. The web sites that popped up were unsparing in their details about the disease, which is caused when the body's immune system attacks a patient's tissues and organs. While lupus can range from very mild to life threatening, Ms. Schlesinger found descriptions that emphasized the grim outcomes. "I will tell you, I was pretty shocked,' Ms. Schlesinger said. "I looked up this thing they thought I had and I saw things like, 'survival rates.'"
    She turned out not to have the disease. But partly because of her doctor's dismissive remarks, she also ended up changing physicians. In interviews, doctors and patients say the Internet has profoundly changed their relationships. With an estimated 100,000 medical web sites, patients can look up any disease, drug or medical condition in seconds. When a doctor so much as mentions a possible diagnosis, many patients rush to their computers to learn more about it. When a doctor suggests a drug, patients go online to find its side effects. And when they arrive at their doctor's office, more and more patients are bearing pages of information printed from web sites. "It's a massive revolution," said Dr. Rita Charon, a specialist in internal medicine at Columbia University's College of Physicians and Surgeons. "It altogether shifts what goes on when a patient comes in with pages of downloaded stuff and half the time the doctor looking at it has never seen it before. There's a whole new set of emotions present." The situation is complicated by time constraints on doctors who are part of managed care groups, said Professor E. Kaavi Morreim, an ethicist at the University of Tennessee College of Medicine. "A lot of patients come in with this sheaf of papers," Professor Morreim said, "A lot of it may be completely irrelevant or it may be bad information--who knows what you're getting off the Net. Now the physician has to spend a lot of time sifting through this stuff and explaining. The physician either resents spending the time or truly doesn't have the time. Then the patient may feel he is being given short shrift."
    Dr. Thomas R. Reardon, a general practitioner from Portland, Oregon, who is the president of the American Medical Association, said that while "we do support patients having access to good, reliable information," the problem is that the information on the Internet varies from sound to irresponsible. "Right now, anybody can put anything on the Internet," Dr. Reardon said. In a statement the medical association warns, "The A.M.A. is greatly concerned that a substantial proportion of information on the Internet might be inaccurate, erroneous, misleading or fraudulent and thereby poses a threat to public health." Nonetheless, Dr. Reardon said, doctors are going to have to adjust. "I think this is the wave of the future," he said. Web sites include those sponsored by responsible groups like the National Institutes of Health and the American Heart Association as well as ones run by purveyors of herbs and supplements or of unproven treatments like coffee enemas for cancer. They include sites put up by hospitals looking for business and by individual doctors, some of whom provide links to articles in medical journals and others who say they have secret cures. They also include countless chat rooms for patients, their families and the worried. More sites are added each day, like one to be available soon to be run by a company formed by the American Medical Association and six doctors' association.
    As Ms. Schlesinger discovered, those who search for medical information soon find themselves buried in it. And some find themselves duped, doctors say. Some fields, like plastic surgery, are almost magnets for misinformation, doctors said. "There is so much plastic surgery on the Net," said Dr. I. Kelman Cohen, a plastic surgeon at the Medical College of Virginia of Virginia Commonwealth University in Richmond. "Look younger, look beautiful, have a peel at lunch and go out shopping in the afternoon." One highly educated woman went to see a doctor who advertises widely on the Internet that he does plastic surgery. The man is actually an oral surgeon, Dr. Cohen noted. "He says he is board certified, but he doesn't say in what," Dr. Cohen said. The woman wanted plastic surgery for her eyelids. Dr Cohen said she ended up needing a skin graft from his group to repair the operation by the oral surgeon. Many patients check out the Internet before they go to their doctors, deciding sometimes what they think their condition is or what drugs they need or which they would refuse to take. Doctors can be taken aback. "Some doctors deal well with it, some don't," Dr. Reardon said. Some doctors make no pretense of being interested in the Internet data of their patients. Dr. Albert Kligman, a dermatology professor at the University of Pennsylvania Medical School, says he knows what is about to happen when he sees a patient carrying in a pile of printouts from web sites. "They say, 'Doctor, I have a few questions,'" Dr. Kligman said. "Then they take out about 200 of them. I tell them: 'I only have 12 minutes. I can examine you or I can answer your questions. Make up your mind.'"
    Other doctors say that even though they may become frustrated when patients look up every symptom, every diagnosis and every drug on the Internet, the information can sometimes do more good than harm. Dr. Michael Lockshin, a rheumatologist at the Hospital for Special Surgery in Manhattan, said: "I've had a bunch of people say, 'I've been chasing down my symptoms and this is what I think it is and my doctor hasn't paid attention to me.' About 50 percent of the time when I see patients like that, they're correct." But more often doctors say they are peeved by the new demands being placed on them, frustrated in their efforts to convince patients that a prescription drug is not a poison or that a treatment detailed on the Internet is not proven and annoyed when patients tend to believe the information from the Web is right and their doctor is wrong. "If they take a drug and they have a lousy response to it, they will go to a web page that says it's a poison," said Dr. Alan DeCherney, an infertility expert at the University of California in Los Angeles. "You send them to the reputable pages but they don't want that. They don't listen because it's not what they want to hear."
    Patients and their families, however, tell a different story. Erin Goldstein, legal recruiter for the McCormick Group in Arlington, Virginia said she turned to the Internet when doctors diagnosed a brain tumor in her mother last year. "I was feeding in keywords as fast as I could," Ms. Goldstein said. It was terrifying, at first, she said, adding: "Everything you read says, 'prognosis very poor,' 'traditional protocols showing little effect.'" But, she said, when her mother's biopsy results came back, Ms. Goldstein at least knew what they meant and she was able to focus her Internet research. Her father, Ms. Goldstein said, "wanted to defer to the doctor's expertise, but that really wasn't sufficient for me." Armed with her Internet research, she said, she peppered her father with questions: "Why did the doctor choose this over that? I know there are these five protocols. Why aren't they doing a different surgery?" She stayed in touch with relatives of other brain cancer patients through Internet chat groups, finding their experience and expertise immeasurably helpful. Others turn to the Internet to learn what their medical test results mean. When John Franz, a 42 year old engineer who lives in Moorestown, N.J., discovered that he had an unusual pattern of blood cholesterol, he immediately turned to the Internet. He went to his doctor to discuss his research, but Mr. Franz said, "He didn't think it was important." So Mr. Franz changed doctors. "Patients now have an active role," Mr. Franz said. "With managed care you almost have to. It's up to you now, and if the doctor's not going to support that, you don't have to be involved with them."
    Medical experts say the most trustworthy web sites are those run by the federal government like www.nih.gov and by national organizations like the American Heart Association. Beyond those sites, however, experts say there are guidelines and even web sites that can help individuals decide whether to trust an electronic site. The American Medical Association suggests checking the source of the information and the financing for the site in judging its reliability. Warning signs include sites that seem to be promoting products or that offer miraculous treatments or cures. The association also says to check how often the information is updated and who reviews it. Other advice comes from Dr. Ragnar Levi of the Swedish Council on Technology Assessment in Health Care, who recently analyzed the problem of determining the quality of information on web sites. Writing in the current issue of the magazine Skeptical Inquirer, Dr. Levi notes that a web site by the Health on the Net Foundation based in Geneva www.hon.ch/honcode/honcode_check.html provides a checklist of questions that can help people assess a site's credibility.

Heroin Addicts Cleaner on Methadone
Nicolle Charbonneau, USA Today- 03/07/2000

Methadone beats detox when it come to getting addicts off of heroin, say two studies in the latest Journal of the American Medical Association. And one concludes that it's time to move the treatment out of specialized facilities and into the doctor's office. Although these findings add to 25 years of research supporting methadone, treatment programs still face serious opposition from politicians such as New York City Mayor Rudolph Giuliani, who thinks the treatment is soft on drug addicts. Methadone maintenance treatment (MMT) involves daily, usually oral, doses of methadone, a man-made opiate that is in itself addictive. While not a cure for heroin addiction, it suppresses drug cravings and wards off withdrawal symptoms without producing a high.   It can be taken for decades without serious side effects. MMT programs usually include counseling. The goal: to reduce drug use and dangerous related behaviors, such as crime, needle-sharing and unsafe sex.
    In the first study, researchers at the University of California, San Francisco followed 179 heroin addicts randomly assigned to either MMT or a 180-day detoxification program. Ninety-one patients got MMT along with two hours a week of counseling for six months. Eighty-eight patients in the detox program received methadone for 120 days, then were weaned off it over 60 days. They also received three hours of counseling a week and other support.   The differences were dramatic. Patients in the MMT group stayed in treatment for an average of 438.5 days, compared to 174 days in the detox group. MMT isn't perfect, however: One year later, MMT patients were just as likely to practice unsafe sex, abuse alcohol, or to have legal, employment or family problems. "Maintenance is more successful at preventing heroin use and needle-sharing," says senior author Sharon Hall, a professor and vice-chair of psychiatry at UCSF. "[Methadone] is the most effective treatment that we have right now." "Detox alone has generally been a dismal failure," says Dr. Bruce Rounsaville, a professor of psychiatry at Yale University in New Haven, Conn., and the author of an accompanying editorial.

MMT is controversial
Substance abuse experts generally agree that MMT works better than detox, according to Rounsaville. But MMT is also controversial, since drug addiction is viewed as a disease by some and as a moral failing by others. In the latter case, says Rounsaville, people think that it's wrong to offer addicts more opiates. Hall disagrees. "We're dealing with a chronic disease," she says, comparing addiction to diabetes or hypertension. There are over 800,000 opiate addicts in the United States, yet only 115,000 are involved in MMT programs. One major reason seems to be access: Most MMT programs are in specialized facilities in major cities. In the second study, lead author Dr. Michael Weinrich looked at how the Scottish cities of Glasgow and Edinburgh have dealt with MMT programs, and he now thinks that a major part of the solution lies with general practitioners. In Glasgow, heroin addicts in the first year of MMT must take their methadone under supervision at a community pharmacy. Afterwards, they must seek their treatment at the office of a physician, who can enroll between five and 20 drug-abusing patients and prescribe methadone. The patients also receive drug counseling from a counselor or trained nurse. By 1998-'99, 41 percent to 73 percent of injection drug users (IDU) in Glasgow were enrolled in the program. In Edinburgh, a similar program had drawn 60 percent to 80 percent of the city's IDUs. Between 1988 and 1993 in Edinburgh, the rates of sharing injecting equipment dropped from 85 percent to 51 percent. The HIV-positive rate among referrals to the program fell from 21 percent to 8 percent. "The integration of primary care and substance abuse treatment is very desirable," says Weinrich, a neurologist at the National Institute of Child Health and Human Development in Bethesda, Md.    Rounsaville's editorial supports the findings of both studies. "It is possible to safely and effectively provide methadone treatment in a primary care setting," says Rounsaville. "If methadone treatment could be offered in primary care clinics, it could become available to anyone who needs it across the country."

Throwing Pills at Kids Is Bad, But It's Only a Symptom of the Real Problem.
Amy Bloom, New York Times Magazine, 3/12/2000

Junior Drugs: One Parent's Testimonial. "We too have tried Adderall and Dexedrine and have the same effects. I am interested in learning more about when the F.D.A. is approving the Ritalin patch!! Our main thing with our daughter is she is a living nightmare in the mornings….because no meds are in her system, with the patch that would solve this up and down reactions they have!…My son age five was just put on Clonidine for his ADHD…It is working wonderfully for calming him down and making him think before acting for once in his life!!…My daughter used to take that only before bedtime to get her to sleep!! So I guess that just proves how each med is different for each child!" From the alt.support.atttn-devidit newsgroup, an online forum for discussing attention deficit disorders.
   I have been treating a young girl since her father's sudden death six months ago. One Saturday night, while her mother is out with her new gentleman friend, she makes what we in the business call a "suicidal gesture," which is much less than a full-fledged attempt, but obviously a sign that all is not well, and not likely to be, any time soon. She is in the hospital from Sunday to Friday. On Friday, the "discharge planner" calls to notify me that my young patient will be returning home that afternoon. Her five days of covered hospitalization are now up, and since she is no longer a threat to herself (no suicidal gestures during the four full days of her hospital stay), and was never a threat to others, the HMO says it is time to go and, by the way, it won't pay for family therapy. I suggest that a weekend of hanging around with her mother and the new beau is not a great treatment plan for an impulsive, nonverbal kid. A few more days might give her a chance to connect to the other kids on the unit, to have several sessions of family therapy with her mother, to come to terms with having found herself in a hospital in the first place. I tell the planner what a great girl this is (she is not a great girl yet; right now she is a sad, confused, self-pitying and irritable girl, but she might become a great girl, with some help) and the planner sighs. "Well," she says, "how about medication?" It is the consensus of her treatment team, including me, that what is needed is more talking, more strolling around the grounds with the sympathetic nurse's aid, whose own father died in a car accident, some intensive help for her and Mom at the hospital and more room to grieve. "Medication for what?" I ask. "For whatever. We could keep her another eleven days with a medication trial."
    Prescribing psychotropic medications for school-age children is a booming business these days. Ritalin's production alone is up 700 percent since 1990, and stories like mine are commonplace. As a result, a battle has arisen between the pro-medication and anti-medication camps: heated, public and utterly spurious. Some children need medication; others don't. The real trouble lies in how we make that assessment. This process begins before the doctor ever sees the patient. The person with the cash, the power and even the transportation usually gets to identify the patient, setting the stage for all subsequent decisions. Which is why women without children were called "barren" and men without were just unlucky; why Freud treated the obstreperous Doras but not their parents; why aged, uncertain parents find themselves in nursing homes against their will. It is especially so when the murky questions of behavior and psychology are raised; is it adolescent moodiness or pre-Columbine sociopathy? Was she born that way or did we make her that way?
    The theoretical basis of family therapy--and common sense--holds that the most vulnerable point in the family structure will reveal its stress first. And the way children show stress is often called "symptoms." Parents, of course, do not always wish to interpret the symptoms, nor are family doctors always trained to read them. Even well intentioned parents who wish to make things better, quickly, may override their child's experience and capacity to express it. For American children right now--especially the fidgety, the distractible and the extra lively-- their vulnerability is made worse by a ghastly convergence of social anxiety, overwhelmed and uninspired schools and widespread fixation on the bottom line.
    Find a symptom, find a treatment, treat it and, in a modern twist, make it no one's fault. Fix them, we say, and these new drugs do "fix" them--quickly, inexpensively and inappropriately. We fix them at a younger and younger age--these days even when they're toddlers. And we do so even when we use medications intended for adults. As a result, four million children are on Ritalin and 2.5 million are on antidepressants. Attention deficit disorder and hyperactive disorder) both formerly known as minimal brain damage, but nicely renamed by the drug companies) do exist, and it would be cruel to withhold Ritalin from children who suffer from them. Just as it would be unfair to stigmatize them as spoiled brats and ridiculous to blame their concerned parents. But these drugs are being wildly prescribed because they are cheaper and less time consuming than psychotherapy and much easier to sell, both to the consumer and to the average family doctor. Prescriptions are less work than conversation and careful evaluation. And handing out medication at lunchtime is easier than creating classes that keep intelligent and curious kids from squirming, daydreaming and talking back. Most of all, we prescribe medications for children who don't need them because the medications are available, and a cure for parental vanity and irresponsibility--along with the single minded greed of HMOs--is not.
    A couple come into my office. They tell me they are happily married and need only a consult on their child, who is "out of control." The husband says that he is a fair disciplinarian (although it seems to me that it must be difficult to get much disciplining done between his arrival home at 8:00pm and the child's bedtime at 8:30pm) and that the mother, full time at home, is a pushover who can neither keep to a schedule nor follow through with suitable consequences. She says that he has no idea what he is talking about, since he is never home, and that he makes unreasonable demands on her and their six year old. I suggest that their family is both under stress and producing it. They cancel the next appointment. They call a year later-- their daughter is on Ritalin because of ADD which is now official, and the kids make fun of her for the daily trip to the nurse. "Can I suggest someone who will help boost her self-esteem?"

Demystifying Sessions on the Couch: A Book Review of
Talk Is Not Enough: How Psychotherapy Really Works by Willard Gaylin
Christopher Lehmann-Haupt, New York Times- 3/13/2000

"Although we live in a society that has become psychologically saturated, psychotherapy still seems to have a somewhat clouded image, " writes Willard Gaylin at the opening of his expert and instructive new book, "Talk Is Not Enough: How Psychotherapy Really Works." The reasons for this cloudiness are several, he continues: first, the growing confusion over what exactly constitutes mental illness (we have engineered "the medicalization of woe," he writes); second, the decline of psychoanalysis's standing over the last 40 years and the emergence of "quirkier, trendier, slicker treatments" ("EST and other forms of cathartic weekend cures"); and finally the sinking of Freud's reputation to "its lowest point since he achieved early fame at the beginning of the 20th century."
    The purpose of Dr. Gaylin's book is to demystify psychotherapy and explain it; as he puts it, "to examine the complex and often perplexing interactions between therapist and patient that produce significant changes in the patient's behavior and perceptions." It is a "book about psychotherapy by a man who still passionately believes in it." Dr. Gaylin translates his passion by defining the fundamentals of therapy and the theories of the school he happens to belong to. A graduate of the Columbia Psychoanalytic Center and now a clinical professor of psychiatry at Columbia College of Physicians and Surgeons, he illustrates his more elusive points with lively case histories from his experience as a therapist. The fundamentals seem obvious: how to pick a therapist; how the initial interview usually goes; what purpose dreams serve; the roles of catharsis, insight, free association, transference and the "much-maligned couch," which he argues can free patients to fantasize but can also sink them into passivity. "One intriguing area of nonverbal communication with which we are all familiar is lateness, a common-place personality trait," he writes. "Chronic lateness is a planned event," and "is the quintessential passive-aggressive mechanism." Just as the patient often feels hostile toward the therapist, "the therapist will have some negative emotional responses to his most cherished patients," Dr. Gaylin writes. "Often it will be impatience ('For God's sake, why doesn't he finally take the woman to bed. She has been waiting for this for weeks.' ). For the most part these must not be explicated."
    But from such practical observations Dr. Gaylin can plunge rather suddenly into his own fundamental theories. For instance, writing about the seemingly simple phenomenon of insight, he recalls the offhand observation of a mentor of his, wondering "if insight isn't really the product of change rather than the cause of it," by which he meant "that the recovered unconscious memories which were presumed to initiate the process of change were actually the products of unconscious changes that had already occurred." With similar plunges Dr. Gaylin takes us back to his training as an analyst at the Columbia Psychoanalytic Center. And he introduces us to the ideas of the center's founder, Dr. Sandor Rado (1890-1972), who rejected Freud's theory of the libido, in which human development was viewed in a psychosexual perspective, and replaced it with a theory that focused on childhood dependency as its central concern. From the vantage point of his training, Dr. Gaylin sees the cure of neuroses as involving the recognition in the present of distorted perspectives that trace back to childhood. Then once patients see, therapist must encourage them to act on their insights in the real world. Because therapists are far from neutral agents, Dr. Gaylin insists, they are required morally to do so.
    So by summing up his techniques Dr. Gaylin attempts to dispel the clouds obscuring psychotherapy. As for Freud, Dr. Gaylin writes that he may have been "an imperfect psychiatrist with a somewhat narrow view of mental illness," but he remains "the father of all modern knowledge of human perceptions and behavior," and his current low standing guarantees "an early rediscovery and resurrection." What is puzzling about Dr. Gaylin's defense of psychotherapy is that he does not directly address its severest critics: the sleep theorists, for instance, who argue that dreams have nothing to do with the unconscious, or the pharmacologists who say that drugs are the only solution to psychological problems, or the empiricists who insist that the efficacy of psychotherapy can never be measured. Strangely, he does not draw on helpful evidence to the contrary, like the latest dream research, which at least allows for the possibility that Freud was right; or experiments with snails suggesting that by inducing certain behavior one can produce physiological changes; or pharmacological research indicating that so far most psychotropic drugs tend to attack symptoms rather than causes. Instead Dr. Gaylin simply asserts: "Psychotherapy is not a fraud. It does work." And then sets about to prove it by identifying what he calls "the most common therapeutic maneuvers that are operative under the general rubric of psychotherapy."
    Well, as things turn out, he does considerably better than mere identification. He makes clear how more than talk goes on in the therapeutic session and why the oddly asymmetrical exchanges of the therapist and the patient can theoretically effect change. But mind and matter are converging faster than is dreamed of in Dr. Gaylin's philosophy. One of these days, we'll understand scientifically why psychotherapy can be so healing.

Frequent Binge Drinking on Rise
Tom Kirchofer, Associated Press- 3/14/2000

Binge drinkers on college campuses are likely to be white, live in a fraternity and have a history of binge drinking in high school. And the percentage of frequent bingers is on the rise, according to a study released Tuesday by the Harvard School of Public Health. The survey, conducted last year, was based on responses to written questionnaires from 14,000 students at 119 colleges around the country. The survey, sponsored by the Robert Wood Johnson Foundation, was published in the March issue of the Journal of American College Health. The margin of error was plus or minus 1 percentage point. The study found the population of frequent binge drinkers rose last year to 22.7 percent of the student population, up from 19.8 percent in 1993 and 20.9 percent in 1997. The percentage of students going on binges stayed roughly the same through the 1990s, but American campuses grew more polarized between students whose binges are severe and students who don't touch alcohol. Binge drinker was defined as a man who drank at least five drinks in a row, or a woman who drank four, at least once in the two weeks prior to the survey. A frequent binge drinker had binged three or more times in the two weeks.
    ``To make the situation harder for college administrators, most of these students do not feel they have a problem, and the large majority consider themselves moderate drinkers,'' said Henry Wechsler, a social psychologist and Harvard researcher who led the study. Meredith Petrin, a 20-year-old Harvard junior, said while many of her peers would probably be classified as binge drinkers by Wechsler, she thinks they generally have a healthy attitude towards alcohol. ``I don't see a problem with it,'' she said. ``It's a good release and it's fun.'' The study found the overall portion of binge drinkers has stayed at about two out of five students since a study was done in 1993, while the proportion of frequent bingers — and nondrinkers — rose. The percentage of students who don't drink at all has been rising steadily, from 15.4 percent in 1993 to 18.9 percent in 1997 and finally, 19.2 percent in 1999, the study found.
    Wechsler said it was unclear why campuses were being increasingly polarized between frequent binge drinkers and nondrinkers. ``It may be that the drawing off of nondrinkers and light drinkers from the drinking scene are making it a much heavier drinking scene,'' he said. ``But that's just speculation.'' The people most likely to binge drink tend to be white and male. The study found that 78.9 percent of students who lived in fraternity or sorority houses were binge drinkers. The students least likely to be binge drinkers were black or Asian, over the age of 24, married, and had not been binge drinkers in high school. While the study found binge drinkers have increased risks of missing class, falling behind in schoolwork, getting in trouble or getting hurt, it also found that such drinkers create ``secondhand effects'' on campus. Students who did not binge drink and lived on campuses where bingeing was common were twice as likely to report being assaulted, awakened or kept from studying by drinking students than were nonbinge drinkers and nondrinkers at campuses where bingeing was less common. Joel Wiegert, a University of Nebraska-Lincoln senior who described himself as a former binge drinker, said he quit drinking to excess when he realized he often said stupid things while drunk, disrespected people and once broke a table. ``It was a cost-benefit analysis for me,'' the economics major said. ``I have yet to come up with one benefit to high-risk drinking.

Finding Hope Amid Despair in Treating Compulsive Disorders
Annette Fuentes, New York Times- 3/21/2000

In hindsight, Debbie McDowell now realizes that the quirks and idiosyncrasies her son Jake displayed when he was very young were the first warnings of an illness that would eventually debilitate her child and test her own mettle as a parent. Jake would wear only shoes with Velcro closures that he could pull tight and his pants had to have skin-tight legs. Little kids do bizarre things, she told herself. What's the harm in indulging him? But when Jake was in second grade, a classmate was hospitalized with a heart infection and required a heart transplant, all of which was patiently explained to pupils by a well-intentioned teacher. "My kid heard 'germ', 'infection,' and 'heart' and O.C.D. was born," said Ms. McDowell of Waltham, Mass.
    Obsessive-compulsive disorder is a biologically based psychiatric disorder characterized by persistent, distressing thoughts or images and accompanying ritual behaviors or mental acts that a person is driven to perform. For Jake McDowell, germs were the initial obsession and hand-washing the compulsion, but his symptoms soon expanded and grew progressively worse. He feared contamination from pesticides on the lawn and household cleaners. And then he could not put on his socks. "I would sit on the floor with him with 25 pairs of the same socks trying to find a pair that would go on." Ms. McDowell recalled. "He said it felt like they had rocks in them. And finally, he couldn't go to school. At 8 & 1/2 Jake thought he was nuts."
    It took a year and a half before Jake's illness was ultimately diagnosed as obsessive-compulsive disorder, a period during which the McDowells endured dead-end encounters with a psychologist who suggested the problem was that Jake's father traveled too much. School officials, noting that Jake had seemed depressed and suspected child abuse, reported the McDowells to state officials. Although no investigation occurred, the episode was wrenching and moved Jake no closer to help. Eventually, Ms. McDowell found a psychologist who gave Jake's problem a name and gave the family hope. "It was like the weight of the world was lifted from his shoulders." Ms. McDowell said. Behavior therapy in combination with medication very quickly improved Jake's symptoms. Today, Jake is 13 and although his condition will not be cured, "he is living a very normal life," his mother said.
    Not all O.C.D. stories have such a happy resolution, but the McDowells' tale proves both how far medical science has come in understanding and treating the disorder and how much remains to be done. Just 20 years ago, the condition was considered a rare anxiety disorder, affecting no more than 0.5 percent of the population. Now it is widely believed that 2 to 3 percent of the population and one percent of children meet the criteria for the disorder. More recent research indicates that among adults with the disorder, onset was before age 15. Yet it can go undiagnosed for many years, in part because its sufferers are motivated by fear and shame to hide their symptoms. For adults, the average time between the first appearance of symptoms and diagnosis is 17 years.
    "It used to be thought that if you saw two or three of these kids in a practice in a lifetime, that would be a lot," said Dr. John March, director of the program in Child and Adolescent Anxiety Disorders a t Duke University Medical Center. "Now it appears the prevalence rate is probably on the order of 1 in 200 children. That's two or three kids in every elementary school. It is about the same prevalence rate as juvenile diabetes." Dr. March credits pioneering research by Dr. Judith L. Rapoport at the National Institute of Mental Health and her 1989 book, "The Boy Who Couldn't Stop Washing", for increasing the recognition of the disorder in children.
    Researchers have yet to identify the cause for the disorder, but brain imaging work by Dr. Lewis R. Baxter, Jr., a neuropsychiatric researcher at the University of California at Los Angeles, has located the likely site of the problem in the basal ganglia, an area of the brain that is connected to impulse-carrying circuits. One of these circuits, involving the orbital frontal cortical thalamic regions of the brain, is supposed to screen incoming sensations and thoughts and determine which are important. Chemical imbalance in this circuitry may cause a "mental hiccup," in which thoughts or actions are repeated incessantly. But what causes the imbalance affecting that circuit is still not clear, said Dr. Susan Swedo, head of behavioral pediatrics at the National Institute of Mental Health. "The circuit is a loop, like a string of Christmas tree lights," she said. "When one goes out, they all go out, so you can't tell exactly where the problem originates."
    But researchers do know that stress can trigger the disorder, as can strokes. Dr. Swedo is also involved in long-term research into common strep infections in children as a trigger for the disorder, a syndrome called Pandas for pediatric auto immune neuropsychiatric disorders associated with strep infections. Pandas cases represent a small subset of all children who have O.C.D. More significant is the role of genetics. One in four children with the disorder has a first-degree relative with a similar condition or with a tic disorder. For one girl from upstate New York, genetics is the likely cause for her disorder. But it was not until her symptoms surfaced at age five that her mother, Arlene, made the connection to her husband's own idiosyncratic behaviors. "He's a hoarder," said Arlene, who did not want her last name used. "No one meeting him would know, although you might think he is slightly compulsive." Arlene's daughter's condition worsened as she got older, manifesting as tantrums and then a compulsion to lick-- the garage floor, electrical outlets, a gym mat at school. Homework was a frustrating exercise and the girl's grades reflected her difficulties.
    When the girl was eight, Arlene took her to a psychotherapist and then a psychiatrist, and neither helped. The psychiatrist even made things worse when he prescribed Paxil, and anti-depressant, which gave the girl symptoms of attention deficit disorder. At her wits end, Arlene went to Marni Jaffer, a psychiatric nurse at the O.C.D. and Anxiety Disorder Service for Children and Adolescents at New York Presbyterian Medical Center in White Plains. "The minute Marni met her she said, 'She's in distress, but don't worry, this is the beginning of the end,'" Arlene recalled. Ms. Jaffer began a widely used approach for anxiety disorders, called cognitive behavior therapy, that lasted for six months, beginning with three sessions weekly. The girl also began taking Luvox, one of several antidepressants approved for treating children with the disorder. In less than a year, the girl was much improved. She was getting A's and B's is school and taking dance classes. Now 11, she goes back to Ms. Jaffer for occasional booster therapy sessions and she still takes Luvox. But, Arlene said, "She is the child I always thought she could be." Her husband is a different story. He had a hard time acknowledging his condition and seeking help. "He's doing much better but he's not willing to talk about it. He sees it as a stigma," Arlene said.
    Early diagnosis and treatment is especially critical for children for several reasons, Dr. March said. Left untreated, the disorder can interfere with children's growth as the rituals come to dominate their lives, crowding out other activities. The disorder also derails a child's normal developmental growth, Dr. March said. Research also suggests that early treatment could prevent depression and other conditions that often exist with the disorder in adults. In just the last decade, treatments for children with the disorder have evolved along with understanding of the disease. The class of anti-depressants known as selective serotonin reuptake inhibitors (S.S.R.I.'s), of which fluoxetine (Prozac) is the best known, is one tool doctors use to bring the symptoms under control. Three of them--Anafranil, Zoloft and Luvox--are approved by the Federal Food and Drug Administration for treating children with the disorder. But research done by Dr. March and others suggests that for many children, the behavior therapy that helped Jake McDowell and the young girl with their disorders, can have equally effective and longer lasting results than medication alone.
    At the O.C.D. and Anxiety Disorder Service for Children and Adolescents, Ms. Jaffer and the clinic's founder, Dr. Flemming Graae, use exposure and response-prevention therapy, a form of cognitive behavior therapy that forces patients to confront the objects of their obsession while preventing them from acting out their rituals. So children obsessed with germs would have to touch or drink from dirty glasses, for example, and then not be permitted to wash their hands. "What you're doing," Ms. Jaffer said, "is putting them in the situation that triggers the symptoms and then showing them that nothing bad will happen, and that they can get relief."  Another proponent of exposure response-prevention therapy, Dr. March has published a manual for practitioners and parents, "O.C.D. in Children and Adolescents", which maps out a treatment through cognitive behavior therapy, or C.B.T. Among his patients, Dr. March said he had an 80 percent success rate in diminishing symptoms. "Fifteen years ago, if you were a kid with O.C.D., you were up a creek without a paddle," he said. "Now, if you can get access to C.B.T., once you get well, you stay well. You may need boosters, but the long-term prognosis is good."