Noteworthy News Articles on Mental Health Topics, August 12- , 2005
Marianne Szegedy-Maszak, Los Angeles Times- 8/12/2005 The day that Marilyn Lancelot won the biggest jackpot of her life, she left the casino in Yuma, Ariz., with every penny of the $4,000 that had poured out of the slot machines. This time she knew that she would never gamble again. She was right, although not for the reasons she thought. The next day, seven police cars appeared in her Phoenix driveway and she was taken out of her house in handcuffs. The 61-year-old grandmother had embezzled more than $300,000 from her employer to support her gambling addiction. "I had something wrong with me," says Lancelot, now 75 and living in a retirement community in Phoenix. "Some people can't think that gambling is an illness but maybe it is. I know that I couldn't stop. My head wouldn't let me." Lancelot's turn of phrase contains clinical truth. Researchers are learning that the heads — or to be more accurate, the brains — of pathological gamblers are biologically different from those of most of the estimated 73 million Americans who are able to play bingo, pull the arm of a slot machine or flip some aces and then simply stop. Not only does the research shed light on how this addiction is both similar and distinct from other addictive disorders, it also could contribute to new treatments. The need is undeniable. With legalized gambling in 48 states, 40 states with lotteries and online gambling available in any home with Internet access and a credit card, the triumph of the occasional big win has been accompanied by a rich yield of individual lives in shambles. About 1.6% of Americans have a full-blown gambling addiction and an additional 2% have a serious problem with gambling, says Jon Grant, assistant professor of psychiatry at Brown Medical School and author of "Stop Me Because I Can't Stop Myself," (McGraw Hill, 2003). By these estimates, nearly 4% of the population experiences a mild to severe gambling problem — and as the number of gamblers goes up, so does the number of those with a gambling problem. In California, "We think that virtually everyone knows someone who has a problem," says Bruce Roberts, executive director of the California Council on Problem Gambling, who has experienced the frightening trajectory of gambling addiction. Officially, about 1 million Californians are considered problem gamblers. Now, with the aid of neuroimaging techniques and a greater understanding of neurotransmitters, researchers are discovering that the brain's hard-wired reward system and frontal lobes have certain unique characteristics in these gamblers. Even some of their personalities and genes may be different from those without gambling problems. "We are finding that pathological gambling is very definitely a brain disease," says Timothy Fong, a psychiatrist and codirector of the UCLA Gambling Studies Program. "The central question is: Were pathological gamblers born that way or are the changes in their brains the results of excessive gambling? We are far from answering that question in a meaningful way." Pathological, or compulsive, gamblers simply cannot stop gambling, even when their losses cripple their lives. The narratives, though as unique as each life, have a similar trajectory: a fascination, then obsession with gambling, punctuated by a few wins and colossal losses often involving houses, jobs, personal relations and savings, finally resulting in a shattered life. Nearly 20% of pathological gamblers have filed for bankruptcy protection, compared with 4.2% of non-gamblers. But perhaps a more telling, and certainly more tragic consequence, is that compulsive gamblers are nearly four times as likely to have attempted suicide than non-compulsive gamblers. The disorder was officially categorized by the American Psychiatric Assn. as a diagnosable disorder in 1980, but was categorized as an "impulse control" disorder rather than an addiction like alcoholism. As research during the last 25 years has revealed, however, it is both. The brain can become addicted to behaviors as well as substances, Grant says. "It can be addicted to anything that we find rewarding," he says. "If we find it too rewarding, we will want to do it again and again. Even when they lose all their money and credit cards, they describe intense cravings much like people do for drugs." The explanation for why gambling is the drug of choice for one person, and for another it's heroin is still unknown. But the key to most addictions can be found in the brain's reward system, particularly a region called the ventral striatum. Neuroimaging studies of compulsive gamblers point to a different functioning in this neural system. A study published in February in the journal Nature Neuroscience compared 12 pathological gamblers and 12 healthy people. While lying in a functional magnetic resonance imaging machine (fMRI), all were asked to choose a playing card by pressing a button. If the card was red, they won money; otherwise they lost money. The task activated the ventral striatum, also known as the nucleus accumbens, an area of the brain that is primed for pleasure and reward-seeking behavior. But the experience of pleasure was far less pronounced for pathological gamblers. The more serious the gambling problem, the less activation of that region. When the area is working normally, it responds appropriately to pleasure stimuli — such as winning money or getting a gift — filling us with a sense of happiness or satisfaction. When it is not working properly, as in cocaine addicts, this area seems almost indifferent. What would make a normal person react does nothing for people addicted to substances or behaviors. Even more stimuli, such as drugs, alcohol or gambling, are needed to feel the pleasure from a particular activity. "You experience something very nice that gives you pleasure," says UCLA's Fong. "But then other parts of the brain seem to shut down and you need to have the reward so much that it takes over the rest of the brain." Marilyn Lancelot remembers the feeling of surrendering to the impulse of playing the slot machines. She couldn't have cared less about horse races or bingo, but the slot machines mesmerized her. "Gambling occupied everything in my mind," she recalls. "When I sat at the slot machines, it was like a switch and they shut off everything real. The slots would become me and my dream world." Research presented at the American Academy of Neurology meeting in April found that executive function, the brain circuitry that underlies inhibition and self-control, was deeply impaired in pathological gamblers. These impairments made the gamblers unable to truly comprehend the trade-off between short-term reward and long-term negative consequences. This loss of self-control in turn affects other important brain functions needed to step on the brakes when emotions spin out of control. Those who suffer from attention-deficit disorder experience difficulty with executive function, and researchers have found, not coincidentally, that a high percentage of pathological gamblers also have ADD. Many studies suggest that compulsive gamblers may have reduced frontal lobe activity, which may in turn be triggered by decreased activity in the basal ganglia, a deeper part of the forebrain that generates two important neurotransmitters called dopamine and norepinephrine. The feel-good neurotransmitter dopamine, in particular, has intrigued those studying compulsive gamblers. Several studies have looked at a dopamine receptor gene and have found real differences in the structure of that gene between gamblers and non-gamblers. That genetic predisposition has direct consequences on brain chemistry. The dopamine receptor sites in the midbrain that are driven by anticipation, but uncertain of the rewards, are especially sensitive. They require more and more dopamine to create the rush of happiness and satisfaction. When gambling is the trigger for the dopamine rush, a vicious cycle is created. A study in the Archives of Neurology last month looked at 11 patients with Parkinson's disease who were taking an artificial dopamine, nine of them took pramipexole and two others took a similar drug called ropinirole. Eventually they all became compulsive gamblers, and seven of them did so within three months A 53-year-old registered nurse, who had gambled only once in five years, began going to casinos once a week. A 54-year-old minister who had gambled only an occasional $20 at a local casino began to gamble almost daily and over several months lost more than $2,500. And a 52-year-old married man who had never had a problem lost more than $100,000 gambling. He also developed a voracious appetite for food and sex, gaining 50 pounds and engaging in extramarital affairs. Although the research focused on medication side effects for those with Parkinson's disease, the study also shed light on both dopamine and compulsive gambling. "This research makes us more sensitive to the idea that there are deficits in certain brain areas of gamblers," says Leann Dodd, a psychiatrist at the Mayo Clinic and lead researcher in the study. "It adds to the evidence that gamblers might have a decreased capacity to get stimulation from their pleasure system and they need extra stimulus to get there." Roberts, of the California Council on Problem Gambling, whose costly "drug of choice" was poker, experienced the physical and behavioral rush of gambling. He made his last bet Dec. 12, 1989, and realized that he had "to get help or die." He had refinanced his home nine times to support his compulsive gambling and had lied about nearly everything to his wife. "Even today I may be flipping through channels and see poker on TV," he says. "It may be someone I played with years ago and I stop to take a look. I can feel my insides changing. It is kind of like a little adrenaline rush, the way you feel when you come close to having an accident on the freeway. You feel your body coming alive to the stimulus." And yet, some people can feel the same excitement and gamble within their means, enjoying the game, while others are completely out of control. Perhaps it is also a question of personality. In a paper last month in the Archives of General Psychiatry, researchers looked at the personality and temperament of 939 men and women, all born in 1972 or 1973, to see if they could discern some personality traits that compulsive gamblers all shared. They also wanted to find out if these traits related to those in substance abusers. All the participants were given a personality test when they were 18, and then at 21 they were screened to see if problem behaviors such as compulsive gambling, drug and alcohol abuse or nicotine dependence, had emerged. The researchers found that the problem gamblers shared many personality traits with others with addictive disorders: risk taking and impulsivity. Until now, treatment has consisted primarily of cognitive behavioral therapy, which can help gamblers control impulses. But increasing understanding of the neurobiology of the disorder may result in new and more effective treatments. One promising treatment is the drug naltrexone, an opioid receptor antagonist. In several preliminary studies, the drug reduced the urge to gamble and when gambling did occur, there was much less enjoyment or enthusiasm for it. Side effects can be unpleasant, and the drug can be toxic to the liver. Antidepressants and mood stabilizers have also been used to treat gamblers, but they have had only mixed success. But, writes Richard Rosenthal, the director of the UCLA Gambling Studies Program, "Medication should be thought of as an adjunct to the treatment of pathological gambling. Most gamblers can be treated successfully without it." Both Marilyn Lancelot and Bruce Roberts credit their recoveries with a treatment program, not with drugs. They changed their behavior and simply stopped gambling. For other people, more intensive supportive therapy is necessary, or even placement in a residential treatment facility where each hour of the day is scheduled. Roberts' life is financially stable and he now organizes educational programs on the human costs of gambling addiction. Lancelot now boasts a triple-A credit rating, works part time and is saving money. In January she will celebrate 15 years of being free from gambling. "I'll bet that the next 15 will be even better," she says. "But I don't bet." Signs of trouble Pathological gambling is classified not under addictions in the Diagnostic and Statistical Manual of Mental Disorders, or DSM IV — the diagnostic bible of the American Psychiatric Assn. — but rather with kleptomania and pyromania as an "impulse control" disorder. A person must demonstrate five or more of the following 10 characteristics to be considered pathological, although some experts say that possessing several of these characteristics can point to signs of trouble. Signs of being a pathological gambler include: • Preoccupation with gambling, reliving past gambling experiences or thinking of ways to get money with which to gamble. • A need to gamble with increasing amounts of money to achieve the desired excitement. • Repeated and unsuccessful attempts to control, cut back or stop gambling. • Restlessness or irritability when attempting to cut down or stop gambling; • Gambling as a way to escape from problems or relieve a depressed or unhappy mood. • After losing money, returning another day to get even or "chase" one's losses. • Lying to family members, therapists or others to conceal the extent of involvement in gambling. • Committing illegal acts such as forgery, fraud, theft or embezzlement to finance gambling. • Jeopardizing or losing a significant relationship, job or educational or career opportunity because of gambling. • Reliance on others to provide money to relieve a desperate financial situation caused by gambling . Non-Soldiers Suffer Post-Traumatic Stress Associated Press, 8/13/2005 GLENVILLE, N.Y. -- For hundreds of thousands of Americans, mental illness is just a drive down the road. Ask Beth Puglisi. The 45-year-old mother was out to fill her gas tank on a bitter-cold January day last year. She turned the wheel of her pickup, felt a wrenching jolt, and watched the roadway fly into a spin. ''No!'' she heard herself screech. The rubbery aroma of spilled antifreeze filled her nostrils. In the days after her crash with a car, she took to the couch, weeping -- but not over her fractured vertebra and dislocated shoulder. Her mind was staggering. ''It felt like a death,'' she says. Her body was quickly tended, but it took months before doctors even put a name to her other injury: post-traumatic stress disorder. Once associated mainly with the horror of combat, PTSD has stretched to take in more frequent swerves along life's road -- car crashes, house fires, a sudden death or severe family illness, witnessing a disaster, or even learning of one. PTSD has broadened the model of mental illness to cover disturbances set off solely by external events, outside of the mind. Almost anyone can be vulnerable. Research suggests the disorder is now present in 5 percent of Americans, or more than 13 million, according to the PTSD Alliance, which unites professionals and advocates. It is expected to touch 8 percent of adults during their lives. By contrast, just over 3 percent of Americans have cancer. Puglisi had been in accidents before, but she never felt this way. She couldn't stop picking over this crash in her mind. It wasn't her fault; it just wasn't. So why did it have to happen? Why? Her family encouraged her to talk: ''Each time I would tell someone about it, I could feel it and smell it -- the whole thing.'' In a kind of flashback typical of PTSD, she could still smell the antifreeze. As PTSD's debilitating anxiety took hold, Puglisi started to feel nervous, flushed, even lightheaded when she was driven to a doctor or physical therapist. She would tremble, and her chest would tighten: ''Just thinking about it was making me crazy.'' When she tried driving again, she'd have to circle around to avoid making the same kind of turn as in the crash. She'd bypass where it happened. Ashamed, she asked her husband to drive the children to their activities. While television droned war news from Iraq, she felt trapped in her own combat zone: ''When you're in the war, you have no idea if you're going to be alive or dead in 10 minutes. That's exactly the way I felt.'' Warring soldiers have carried home psychological scars for centuries. The ancient Greeks noticed it. In American wars, it has been called shell shock, combat fatigue and post-Vietnam syndrome. Though skeptics discounted some cases as shams meant to win compensation, other extreme cases were taken for schizophrenia. Medical authorities first accepted PTSD as a distinct psychiatric condition in 1980 at the urging of Vietnam veterans and their medical caretakers. In PTSD, stress hormones like adrenaline scorch a painful event deep into long-term memory, scientists believe. Lab studies show such hormones normally improve memory in animals. They seem to overshoot the mark in PTSD. People get very edgy and fearful, prone to nightmares or flashbacks. They desperately want to avoid reminders of their shock, even to the point of feeling numb. PTSD happens more often in women, in cases of multiple traumas (Puglisi had another road accident just a couple weeks earlier), and in people with depression. Once defined, the disease was soon embraced, and insurance coverage expanded. Here was a psychiatric condition touched off by concrete events, not something hidden in the mind's dim recesses. It could theoretically happen to anyone, even the hardiest and soundest of mind. It wasn't your fault. The federal government established the National Center for Post-Traumatic Stress Disorder. It began researching PTSD and treating hundreds of thousands of veterans. Survivors from rape and car crashes began to seek therapy in greater numbers too. In 1994, the sudden death of a relative, or even learning that one was hurt, joined the expanding list of PTSD traumas in the chief diagnostic manual for psychiatry. By the late 1990s, when Dr. Greenbrier Almond was working as a psychiatrist at a West Virginia veterans hospital, PTSD was already its leading diagnosis, above heart disease and diabetes, he says. Over the past five years, the number of cases among veterans -- mostly from combat -- has exploded nationally by almost 80 percent to 215,871 last year, according to the Department of Veterans Affairs. It is the agency's fastest-growing disability. No similar statistics are collected for civilians, but the numbers are clearly substantial. Dr. Almond, who has left the veterans hospital, now treats PTSD in abused children at a community health clinic. Research at Henry Ford Health System, Harvard and Georgia State has identified the two leading causes of PTSD as unexpected deaths of relatives and car crashes. Combat ranks far down on the list. Some bad diagnosticians and purveyors of pop culture have come to consider just about any of life's shocks -- divorcing, losing a job, even failing a test -- as triggers for PTSD. Though veterans officials say rising awareness has driven most of their growth, they are also reviewing whether some cases have been diagnosed too readily. ''Anything that happens to you that's remotely icky now qualifies,'' says psychologist J. Gayle Beck, at the University at Buffalo-State University of New York. ''It's been culturally overdiagnosed.'' This psychiatric illness has carried cultural baggage since its birth in the social turmoil over the Vietnam War. The new disorder tied to external events meshed with a Kafkaesque view of society inherited from the 1960s: Outside forces constantly threaten peace of mind. Since 2001, PTSD has tapped into another source of anxiety: terrorists who can inflict mass death in an instant. A survey found highly elevated rates of PTSD in the New York metropolitan area, where the smoking towers of the World Trade Center could be seen for miles. Afterward, some companies sent reassuring notices to workers listing PTSD symptoms and saying they were common responses. One compared them to a minor flu. ''It speaks to dangerous times and threats, and that certainly defines our era,'' says Dr. Robert Jay Lifton, a Harvard University psychiatrist who helped define PTSD as a condition. ''There is bound to be widespread PTSD and an awareness of it.'' Even so, many people with PTSD still do not come forward for help, caregivers say. And even experts may miss the signs. ''My father dropped dead in front of my mother. She developed PTSD for two years, and I was completely unaware of it. I knew something was wrong, but I didn't know it was PTSD,'' says psychologist Terence Keane. Yet he is director of behavioral science at the federal PTSD center. The good news is this: Even untreated, PTSD goes away in about half of the cases within six months, research indicates. The bad news: When it doesn't, it can last for decades. Puglisi had never needed therapy before and didn't think of treating her embarrassing automotive anxiety. ''I would say I'm all right,'' she recalls. But she wasn't. Her doctor told her she'd soon get over it, but her physical therapists knew better. After several months, they persuaded her to look for help. She found Edward Hickling, a former veterans psychologist who now specializes in road-accident PTSD. ''I came to private practice, and I saw motor-vehicle accident victims that looked a lot like ... the post-traumatic stress responses I saw in the veterans hospital,'' says the therapist based in nearby Albany. Like many PTSD therapists, he relies on cognitive behavioral therapy. A common psychological treatment, it teaches how to replace negative mental monologues (''I could die on the way to work'') with positive, rational ones (''I'll probably get there just fine, as usual''). It can be carried out one-on-one or in groups. Like many PTSD therapists, Hickling re-exposes participants to memories of the terrifying situation, while desensitizing them over a few months or longer. They start by telling what happened and graduate to driving back to the crash site. One woman was able to drive back and gaze at the place where her car plunged down a hill, trapping her for more than two hours. Later, she felt as though she had ''removed a cloud from her brain,'' according to Hickling. The therapy can work in up to 75 percent of road-accident survivors with chronic PTSD, research suggests. Some patients, though, can't tolerate thoughts of their ordeal. ''It's just too painful,'' says psychologist Charles Figley, at Florida State University. Lesser symptoms persist in many people. Psychiatrists often treat PTSD with drugs. The federal government has approved two depression medicines, Zoloft and Paxil, for PTSD. Research suggests they help at least a quarter of PTSD patients. Other researchers are experimenting with potential PTSD drugs like anti-adrenaline agents and the antibiotic D-cycloserine. In theory, they might disrupt the consolidation of long-term PTSD memories or help the brain forget them later. Psychological therapy alone conquered Puglisi's symptoms, though it took a year. She still hasn't gone back to work but doesn't feel so alone. Now she knows of many others like her: ''The mind does this sometimes.'' What happened to her, she has learned, is normal.
Clifford Krauss, New York Times- 8/13/2005 VANCOUVER, British Columbia- Freshley released on bail, Marc Emery faced the camera of his Pot-TV.net Web site the other day to make an urgent appeal for money to finance his legal struggle to avert extradition to the United States for trafficking marijuana seeds south of the border. Let me be the light that shines on the American gulag," he said, stern-eyed, pointing into the camera. Without notes, Mr. Emery sermonized for a half-hour about everything from the marvelous medicinal and spiritual qualities of pot to the greatness of Thomas Jefferson, "who gave America on hemp paper the Declaration of Independence." "Marijuana made me a better parent, a better lover, a better businessman," he solemnly told his supporters. Immediately after the broadcast, he was quick to add, "a better driver, too." At 47, Mr. Emery is known as the Prince of Pot, even in his recent federal indictment in Seattle for charges of conspiring to manufacture marijuana, launder money and traffic millions of marijuana seeds into the United States. At the time of his arrest, on July 29, he and his business were on a United States attorney general list of the 46 most wanted international drug traffickers, and the only one in Canada. But his clownish nickname provides a clue that Mr. Emery is not your typical drug kingpin from the movies who deals in the shadows. A lanky Canadian with a taste for bland T-shirts and chinos, he proudly promotes himself as the leader of the sizable Vancouver marijuana counterculture that is condoned by the municipal government and much of the city's population. He postures as just a regular guy who loves the Vancouver Canucks, and rarely smokes more than a joint or two a day. But he also freely says that, outside the Netherlands, he has sold more marijuana seeds and offered the largest selection of any seed bank in the world. He adds that the amount of seeds he has sold south of the border "qualifies me for the death penalty in the United States." (The first claim, of ubiquity, is accepted by American prosecutors, while the second, of a looming death sentence, is met with guffaws.) "I have a master plan," Mr. Emery said in an interview in the offices of his magazine, Cannabis Culture. "I've wanted to be the Johnny Appleseed of marijuana, so if we produced millions and millions of marijuana plants all over the world, it would be impossible for governments to eradicate or control all of it." In other words, he added, he wants "to overgrow the governments" that punish marijuana users. In his crusade to make marijuana completely legal everywhere, not just in Canada, where anti-pot laws are already more lenient than in the United States, Mr. Emery has marketed his seeds and anti-prohibition message on his Web site and magazine and traveled around the country smoking marijuana in front of police stations. As leader of the British Columbia Marijuana Party, he has run candidates across the province and has himself run for mayor twice in Vancouver on the platform of disbanding the police force and remaking it from scratch. Armed with a speaking style that resembles a tommy gun firing off sound bites, he came in a respectable fifth out of 16 candidates in the last mayoral election, in 2002. To the growing annoyance of American law enforcement, he has been openly selling seeds to American growers and counseling them how best to cultivate his product and avoid the attention of the police - all with only minor harassment, until now, from Canadian law enforcement. According to the United States Drug Enforcement Administration, Mr. Emery has sold millions of dollars worth of seeds to growers in California, Florida, Indiana, Michigan, Montana, New Jersey, North Dakota, Tennessee and Virginia. "He operated his business very efficiently, making a lot of money at the expense of our kids and the American public," Rodney Benson, special agent in charge of the D.E.A. field division in Seattle, said in an interview. Now, his master plan is in serious jeopardy. In July, the Canadian police, working with D.E.A. agents, arrested Mr. Emery and raided his headquarters at the request of the American government, so that he might be extradited for trial in Seattle. Last week, he was freed on bail; the extradition process could take years. It is bound to stir a debate in Canada about whether it should permit a Canadian to stand trial in the United States for an offense that is essentially tolerated here. But for the time being, Mr. Emery's empire is in tatters. He has been forced to lay off workers at his magazine and Web site, and because he can no longer sell seeds, his ability to finance marijuana-legalization causes has dried up. He says he must move to a smaller apartment, give up his car lease and live on the equivalent of $32 a day from donations. "Lets face it," Mr. Emery said in an interview. "I've sold millions of seeds and I've been doing it every day of my life the last 11 years. I'm so transparent that everyone from the prime minister to the guy on the street knows it." He says he has made $4 million in profit since 1996 selling seeds in his Vancouver store, by mail and on the Internet. But he says he has not saved a dime, does not own a share of stock or bonds, does not even own a piece of property. All the money he has made, he says, has gone into his magazine, his Internet Pot-TV news channel, his British Columbia Marijuana Party, various referendum initiatives for marijuana legalization in the United States, legal fees for marijuana growers in several countries and support for his wife, various ex-lovers and four adopted children. He also claims to have paid nearly $600,000 in taxes from the proceeds of his seeds, noting openly on his tax returns that he worked as a vendor of marijuana seeds. Mr. Emery describes himself as "a responsible libertarian, not a hedonist," who extols the virtues of capitalism, low taxes, small government and the right of citizens to bear arms. He said he grew up a social democrat, influenced by his father, who was active in trade union work. But he said his life changed in 1979 when he began reading the works of Ayn Rand, who championed individual freedom and capitalism. "The right to be free, the right to own the fruits of your mind and effort now all made sense," he recalled. Only a few months after discovering Rand, his girlfriend at the time offered him a joint and he smoked marijuana for the first time. It was an epiphany," he said. "I had a sixth sense added to my five senses. The silence sounded different, smells were more nuanced and the brightness of the moon made it look bigger and more substantial in the sky." The combination of Rand's philosophy and the marijuana set him on a course of advocacy in which, he said, "I decided to dedicate my whole life to repudiate the state." Then living in London, Ontario, he sold banned marijuana and pornography books and magazines, contested laws limiting the right of stores to open on Sundays and led a municipal tax revolt. He even resisted a municipal garbage strike, by renting a truck and picking up the garbage himself. After traveling for a while in Asia, however, he has dedicated his efforts to promoting marijuana and its culture. "Now the Goliath, now the evil empire has made its move on me," Mr. Emery told his Web site audience. But he promised that his crusade would continue "till liberty or till death."
Sally Jacobs, Boston Globe- 8/14/2005 The letter is written in girlish, excitable script. It is an appeal from a scared young woman to her father. In it, she confides that she has ''a little problem." The problem is a baby. But amid all the run-on sentences and exclamation points, Danielle M. Jones could not quite bring herself to write the word ''baby." Instead, she enclosed a copy of her ultrasound. When she wrote the letter in January she was seven months pregnant with her second child. She was not married. ''Please, please forgive me," Jones, 25, wrote. Telltale symptoms Difficult childhood Culminating factors Sally Satel, M.D., New York Times- 8/16/2005 Patients arrive broke, busted or abandoned at our methadone clinic in a raw section of Northeast Washington. They are opiate addicts, primarily dependent on heroin, though some take vast doses of street-bought painkillers like OxyContin. Drinking the pink methadone solution every day prevents withdrawal sickness. About half of our patients have also spent years on crack or alcohol. Not all have stopped, but at least they have cut back. We see almost no methamphetamine users, but that is a simple accident of geography -- the corrosive drug hasn't yet reached epidemic proportions in this part of the country. The personal ravages of hard-core addiction are enormous, and they translate into vast social costs -- crime, violence, incarceration, homelessness, unemployment, hepatitis C, H.I.V./AIDS. Such an immense burden makes me wonder about the wisdom of federal priorities. Why is marijuana, of all drugs, the main target of the White House Office of National Drug Control Policy? Answer: the gateway theory of addiction. Start with marijuana, the idea is, and progress to methamphetamine or heroin or cocaine. To me, the "gateway" assumption, which took root in the 1950's, has a nostalgic, "Reefer Madness" feel. But it is still driving federal policy. The drug czar's office made that clear last month in response to a call from the National Association of Counties "to put the same kind of emphasis on methamphetamine abuse as they have on marijuana." The association had just announced that its 500 members were reeling from methamphetamine-related crime, incarceration and child-neglect. The Office of National Drug Control Policy defended its prioritization. Addressing "early marijuana use is an effective way of heading off and preventing subsequent movement into other drug use," said a spokesman for the drug czar on National Public Radio. Is this true? Is the gateway argument a valid justification for marijuana policy? No reasonable person disputes that most users of cocaine and heroin have smoked marijuana earlier in life. Likewise, the more frequently people consume marijuana the more likely they are to try hard drugs. But what is the nature of the linkage? Is it actual cause and effect, as the drug czar's office implied, or a correlation based on a common factor that predisposes youth to drug use in general? And how frequently do we observe such a progression? One theory is that teenagers who smoke marijuana without incident are emboldened by the experience to try other more risky and exotic drugs. And perhaps buying marijuana brings them in contact with dealers of stronger drugs. Or possibly cocaine and heroin abusers would have developed their drug problems no matter what. As RAND researchers reported in a 2002 article, "Reassessing the Marijuana Gateway Effect," "Marijuana use precedes hard drug use simply because opportunities to use marijuana come earlier in life than opportunities to use hard drugs." A relatively newer theory suggests that marijuana sets up the user's brain to be more receptive to harder drugs. A much-publicized 1997 study from the Scripps Research Institute reported that cannabis activates the same reward circuitry in the brain as cocaine, heroin, tobacco and alcohol. But this has dubious relevance to future addiction. After all, almost any normal pleasurable activity, like eating or sex, also stimulates those pathways. In any event, a brain activation effect couldn't be too powerful, as most casual marijuana smokers do not graduate to the abuse of hard drugs. Only about 3 percent of monthly cannabis users go on to try a hard drug in the same year, according to data from the National Survey on Drug Use and Health. And roughly one-fifth of those who try cocaine eventually become addicted; perhaps one-third of heroin experimenters do. Social scientists have found that adolescents who progress to hard drugs are already quite troubled to begin with. Truancy, failing in school, fighting, stealing and drinking often come before heroin or cocaine involvement. Marijuana use before age 15 is also a red flag indicating psychological turmoil and social instability. By contrast, older teenagers who experiment with marijuana generally function as well as nonusers with respect to school and mental well-being. These observations are consistent with my own clinical experience. As staff psychiatrist for the clinic, I have taken over 500 detailed histories of adults with opiate addictions. Marijuana was the least of their problems when they were young. More often, they were staggering under the weight of a chaotic home life and had dropped out school, committed petty crimes and battled depression. These problems, not marijuana, led them to hard drugs. Efforts to prevent new generations of addicts are noble, but they should be rational too. It's hard to say whether any one policy a drug czar could devise would have derailed the early trajectories of my patients' lives. But it is clear that such a large investment in the gateway theory has been of little help Sally Satel is a psychiatrist and resident scholar at the American Enterprise Institute and a co-author of "One Nation Under Therapy." |