Noteworthy News Articles on Mental Health Topics, February 1-5, 2006



Study: Pregnancy May Not Help Depression

Associated Press, 2/1/2006

CHICAGO -- Pregnant women who stop taking antidepressants run a high risk of slipping back into depression, a study found, busting the myth that the surge of hormones during pregnancy keeps mothers-to-be happy and glowing. The study offers new information but no clear answers for expectant mothers who must balance the risk of medications harming the fetus against the danger of untreated depression. ''It's important that patients not assume that the hormones of pregnancy are going to protect them from the types of problems they've had with mood previously,'' said study co-author Dr. Lee Cohen of Massachusetts General Hospital. The study does not deal with postpartum depression -- the depression that sets in after delivery, and is often blamed on hormonal changes. The research looks only at depression during pregnancy, a condition far less understood.
      No one knows how many pregnant women are on antidepressants, but it is safe to say millions of women of childbearing age take them. Medco Health Solutions estimates 8.4 million American women ages 20 to 44 take antidepressants. Other research has shown risks to the fetus, including possible heart defects, from antidepressant use during pregnancy.
     Researchers followed 201 pregnant women with histories of major depression who were taking drugs such as Prozac, Zoloft, Effexor and Paxil. Because of ethical concerns, the researchers did not randomly assign the women to either stop or continue medication. Instead, the women decided what to do, then researchers watched what happened. Sixty-eight percent of those who stopped taking antidepressants slipped into depression. They were five times more likely to suffer a relapse than the women who continued on drugs. But staying on antidepressants did not shield expectant mothers from depression entirely; 26 percent of those who continued drug treatment became depressed anyway.
     Dr. Katherine Wisner of the University of Pittsburgh School of Medicine said the study makes an important contribution by quantifying the risk of relapse. She was not involved in the study but does similar work. ''I was taught in my residency that women don't get depressed during pregnancy,'' said Wisner, who was a psychiatry resident in the early 1980s. But ''I had patients who were depressed. I asked my supervisor, `You mean I'm really not seeing patients who are depressed?''' The study appears in Wednesday's Journal of the American Medical Association and was funded by the National Institute of Mental Health. Two of the co-authors declared in the paper that they have financial ties to several antidepressant manufacturers.
     Other researchers have shown that antidepressant use during the last three months of pregnancy can make newborns jittery and irritable, and sometimes can cause them serious breathing problems. In addition, the Food and Drug Administration has warned that Paxil may be linked to fetal heart defects when taken during the first three months of pregnancy.
     Dr. Peter Kramer, author of ''Listening to Prozac'' and ''Against Depression,'' said the study provides information that can help women and doctors decide what to do. ''Ideally, everyone would like to go through pregnancy off all medication,'' Kramer said. ''But these are serious issues, and both decisions can be justified.'' Kramer suggested some women might want to get off antidepressants but schedule more psychotherapy while pregnant.
     On the Net: JAMA: http://jama.ama-assn.org



U.S. Probes Massachusetts Psychiatric Hospital
Josh Kovner, Hartford Courant- 2/1/2006

MIDDLETOWN -- The U.S. Department of Justice is investigating whether the state's largest public psychiatric hospital protects patients from harm and uses seclusion and physical restraints properly. The Justice Department's civil rights division began an investigation of Connecticut Valley Hospital on Dec. 15, and federal investigators will inspect the Middletown campus in mid-March.
Wayne Dailey, spokesman for the state Department of Mental Health and Addiction Services, acknowledged Wednesday that the visit was "not routine."
     Sweeping management changes were made at CVH and its Whiting Forensic Division in November. Dailey said those changes were in the works for more than two months, before state officials learned of the federal investigation. Eric Holland, a Justice Department spokesman, declined to comment on the probe Tuesday. The division, under the Civil Rights for Institutionalized Persons Act, investigates substantial complaints and potentially illegal conditions inside mental-health centers, jails, nursing homes, juvenile facilities and other institutions. A source at CVH said a Justice Department official in the civil rights division asked questions in November about suicides at CVH in 2003 and 2004.
     The hospital had been staggered by three suicides in a 15-month period, including two in 10 weeks. An investigation by the state Department of Public Health found that serious breakdowns in basic nursing preceded two of the suicides. In those cases, nurses failed to respond to telltale behavior by two patients with a history of suicide attempts. One of the nurses was a "traveling nurse," a temporary employee who had been found incompetent at her job but was still placed in a supervisory position. The hospital made a series of changes after the suicides, including increasing training and installing suicide-proof shower heads in one of the units, but patient advocates said the suicides were "arguably preventable."
     Last September, the family of one of the suicide victims, Joseph Sawyer, 21, who died at Whiting, filed a wrongful death lawsuit against the state. The suit alleges flawed policies and negligence and inadequate training on the part of some staff members. A month before Sawyer hanged himself in his room at Whiting, he had attempted suicide in a similar manner in the same room. The state Office of Protection and Advocacy for Persons with Disabilities investigated Sawyer's death and found evidence of neglect in Sawyer's treatment at Whiting.
     In 2004, the family of James Bell, a former patient at Whiting who died of a heart attack while in restraints in 2002, filed a $4 million lawsuit against Whiting and CVH. A division of the U.S. Department of Health and Human Services had cited CVH in 2001 for several instances of improper use of restraints.
     This past November, a 36-year-old male patient at CVH was charged with first-degree sexual assault and unlawful restraint in an attack on another patient in Merritt Hall, a substance-abuse treatment and general psychiatry unit at CVH. Four days after the rape was reported, state mental health officials announced that CVH's chief executive officer, Garrell S. Mullaney, was retiring; its chief operating officer, Michael Niman, was being reassigned; and the director of Whiting Forensic, Richard Bennett, had "resigned in good standing." Dailey reiterated Tuesday that the management changes had nothing to do with the sexual assault, the suicides, or any other incident, and he praised Mullaney's stewardship of CVH. Mullaney, a former U.S. Marine and a former prison warden, had presided over improvements in the relationship between CVH and its host city of Middletown. He intends to retire at the end of this year and has taken a post as project director for facility design in the office of Mental Health Commissioner Thomas Kirk.
     Dailey said state mental health officials were told by the federal investigators that they were reviewing "whether there have been systemic problems regarding the protection of patients from harm and the use of seclusion and restraints. "We don't know specifically what triggered their interest; they haven't given us that information," said Dailey. "They did tell us they have not formed any conclusions." After the management shake-up, "the facility is in a state of holding its breath. There's a sense there's going to be major changes," said Susan Aronoff, a lawyer with the Connecticut Legal Rights Project, a patient advocacy group based on the CVH campus.



Drug Shows Promise in Curbing Compulsive Gambling, Study Says
Robert Lee Hotz, Los Angeles Times- 2/1/2006

For the estimated 6 million compulsive gamblers in the U.S., the long odds are on a pill. In the largest clinical study of its kind, researchers at the University of Minnesota found that daily doses of an experimental drug called nalmefene, often used to treat alcoholism, appeared to curb the craving to gamble.
     The research represents the latest effort to control the biology of misbehavior at a time when celebrity poker, online gambling, lotteries and sports betting have helped to make obsessive wagering a national psychiatric disorder. "The study is part of emerging evidence that gambling, once thought to be a problem in moral integrity, is instead a problem in brain biology and can be successfully treated," said Dr. Robert Freedman, editor of the American Journal of Psychiatry, which published the study today in its February issue. The study was sponsored by BioTie Therapies Corp., a Finnish biotechnology company that manufactures nalmefene.
     The researchers tested the drug in a controlled trial involving 207 people undergoing treatment for compulsive gambling at 15 centers across the United States. Almost two-thirds of the patients who were given nalmefene showed "significant" improvement during the four months of treatment, while about one-third of the patients in the placebo group responded favorably, the researchers reported. About a third of the original participants dropped out due to nausea and other side effects. The new compound "offers a real promise of hope for folks with this problem," said Dr. Jon E. Grant, a University of Minnesota psychiatrist who led the study.
     In efforts to treat pathological gambling, researchers have long sought some way to control cravings long enough for more conventional counseling to become effective. Part of the difficulty is that compulsive gamblers often are not easily convinced that they have a problem. "Gambling itself is quite pleasant," Grant said. "It is the fallout — bankruptcy, divorce, jail — that is unpleasant. It is difficult to keep people in treatment."
     In the search for a biomedical solution, researchers have experimented with medications such as serotonin inhibiters and lithium, which have shown mixed results in limited studies. One promising treatment for pathological gambling, involving a drug called naltrexone, has been linked to severe liver damage. "Up to now, we only had inklings that a pharmacological agent would be successful," said Grant, who said he had no financial stake in BioTie.
     The key is to take the compulsive thrill out of winning and losing. Nalmefene interferes with brain opiate circuits that process sensations of pleasure. It also indirectly affects the brain's dopamine system, which handles feelings of reward. Treated with nalmefene, the patients reported that gambling no longer seemed as thrilling or compelling. "It is not a magic pill," Grant cautioned. It may be most effective when used in conjunction with traditional counseling and therapy. To better understand proper dosages, the researchers are conducting a second clinical trial involving 200 patients at 20 treatment centers, he said.




Woman in California Postal Shootings Had History of Bizarre Behavior

Dan Frosch, New York Times- 2/3/2006

GRANTS, N.M.— Two months before Jennifer San Marco fatally shot six postal workers in Goleta, Calif., and killed herself, the police here were alerted to her bizarre behavior, the office manager of a mental health clinic said. The manager, Darlene Hayes, who works at Cibola Counseling Services here, said she saw Ms. San Marco, 44, alone in a post office parking lot, kneeling at her car and talking to herself. When she asked whether Ms. San Marco was all right, Ms. Hayes said, Ms. San Marco replied, "They pray before they get in." Ms. San Marco told Ms. Hayes that she was talking about her brother and her sister, who she said were there with her.
      Ms. Hayes, who has worked at mental health clinics for 18 years, called the police because she thought Ms. San Marco needed immediate psychological attention. After waiting several minutes, Ms. Hayes left the post office, anticipating that the police would help Ms. San Marco obtain a mental health evaluation. "It seemed liked she was acting delusional," Ms. Hayes said. "I wanted the police to make contact with her and hold her for 24 hours so they could determine whether she needed a physician." Lt. Maxine Spidle of the police said the department had no record of Ms. Hayes's call.
     Ms. Hayes's encounter was hardly unique in this ramshackle dust-swept strip of a town near Milan, where Ms. San Marco had lived for the last two years. To her neighbors, she was the woman who shouted furiously to herself, who ordered food at restaurants and bolted out the door before eating it, who knelt in prayer at the roadside and who peeled off her clothes in random parking lots. Nobody knew where she came from or what she was doing here. People just knew there was something wrong. "She would just come in here and stare at me," Sonya Salazar, who works in Milan Village Hall, said. "We knew she had mental problems. We just felt sorry for her."
     In July 2004, Ms. San Marco applied for a business license to start a publication, The Racist Press, Deputy Clerk Terri Gallegos said. It was denied. Ms. San Marco's effort to license a cat food company was also denied. On March 3, 2005, Ms. San Marco angrily visited Village Hall. She grew so irate that somebody called the police. By the time Chief Jerry Stephens arrived, she was gone.
     On Thursday, postal inspectors, joined by local law enforcement officers, an explosives unit from the Albuquerque airport police and deputies from the sheriff's department in Santa Barbara County, Calif., searched Ms. San Marco's yellow two-story house on three acres of dusty hillside. They seized three boxes of "items of interest," a spokeswoman for the postal inspectors, Amanda McMurrey, said.
     Not everyone here had unsettling encounters with Ms. San Marco. For more than two years, Abel Ortega delivered propane gas to her. Mr. Ortega said she was polite and paid her bills promptly. Still, he said, he could not help noticing her behavior. "We'd see her praying by the road, or talking to herself," he said. "She had this imaginary friend."
     Milan residents, in shock over the killings on Wednesday in California, including that of a former neighbor, are beginning to ask why Ms. San Marco was not receiving psychiatric help. Such care is scant in Grants and Milan, which are about 70 miles west of Albuquerque. Aside from a general hospital and a few clinics, there is just a handful of mental health providers, said Vince Ashley, chief executive officer of Cibola General Hospital.
     It is unclear what treatment Ms. San Marco did have. The Santa Barbara County Sheriff's Department has said she was briefly committed in California in 2001, but it has not disclosed additional information. Experts in mental health treatment said they were not surprised that Ms. San Marco was not receiving hospital treatment. Experts said that even in a place like Santa Barbara County, which has a reputation for reaching out to the mentally disabled, people slip through the cracks. Patients' rights laws make it difficult to commit people against their will or force them to take prescribed medication. "It is very difficult to contain someone in a treatment facility as compared to how it was a decade ago," said Barry R. Schoer, executive director of the Sanctuary Psychiatric Center, a private center in Santa Barbara.
     Forty-two states, including California, have established commitment laws for people in and out of treatment who show signs of being a danger to themselves or others. They are collectively known as Kendra's laws, after Kendra Webdale, who was killed when a schizophrenic who had been in and out of treatment centers pushed her in front of a New York City subway train in 1999. New Mexico does not have such a law, but legislators are considering a bill to establish one.



Searching for the Person in the Brain
Benedict Carey, New York Times- 2/5/2006

At this rate, it seems that neuroscientists will soon pinpoint the regions in the brain where mediocre poetry is generated, where high school grudges are lodged, where sarcasm blooms like a red rose. In the last month alone, researchers working with brain imaging machines have captured the neural trace of schadenfreude and the emotional flare of partisan thinking and whatever happens between the ears of a happily married woman when her husband takes her hand.
      As the magnetic resonance imaging machines produce pictures with higher resolution — and that is happening fast — hundreds of such studies are being published in scientific journals each month. Meanwhile, a parallel stream of popularizing books, magazines and newspapers, including this one, are publicizing an ever-enlarging array of the now familiar red, gray and blue graphics of imaged brains, and some of them are making extravagant claims for their significance. Already, lawyers have used M.R.I. brain images to help reduce criminal sentences, arguing that their clients' actions can partly be explained by the way their brains function, or malfunction. Some researchers say their imaging methods can help detect lies. And last week CBS picked up a one-hour pilot for a show that revolves around brain surgeons in Los Angeles and could feature as many close-ups of gray matter as of actors. "The whole reason they were attracted to the idea was the brain itself," said Peter Ocko, the scriptwriter. "The mysteries of the brain are really the star of the show."
     In a word, the brain has become a pop star. But is its glossy, computer-enhanced image a superficial one? What does it really tell us about how we function, what motivates us, who we are? An image with this much charisma surely presents opportunities to re-imagine ourselves in a better light; but what are the hazards inherent in fawning over what are, after all, computer graphics? Neuroscientists themselves debate these questions constantly, and even agree, if uneasily, on some of the answers. First, it is beyond doubt that brain images reveal real biological activity that is associated with genuine human sensations. "This is what accounts for the sheer delight, the true amazement people have when they see these images: they show that there is a measurable physical response in the brain to things like being in love," said Dr. Lucy Brown, a neuroscientist at the Albert Einstein School of Medicine in the Bronx. "Everyone thought phenomena like love and jealousy were simply impossible to study, that they were too variable, too individual. They preferred to think of them as magic."
     Imaging and other techniques have now parted the curtain. The lozenge-shaped amygdala is central to the experience of fear. The delicate-looking horseshoe-shaped area called the hippocampus is crucial to the forging of memories. The visual areas are in the back of the brain. There is even evidence that people have "grandmother neurons" — single cells that recognize a unique face. In once recent paper, Dr. Itzhak Fried, a neurosurgeon at the University of California, Los Angeles, and Dr. Christof Koch, a neuroscientist at the California Institute of Technology, reported that a single cell in the hippocampus of a patient being prepared for epilepsy surgery fired vigorously and consistently in response to a picture of the actress Jennifer Aniston, but far less so when the patient looked at other photographs.
     Understanding that the shiver of celebrity recognition, or the whole-body ache of longing, leaves a physical trace in the brain seems to give people more sympathy for others' emotions and reactions, say neuroscientists who have presented findings in front of professional and lay audiences. "Suppose you know someone who's having trouble, who's suffering from bipolar disorder or depression, and nothing has helped, no therapy, nothing," said Dr. Brian Wandell, a psychologist at Stanford University who studies the visual cortex. "It's nice to know from this new science that there may be some other way to alter the system" than treating it like a character flaw.
     The catch is that, for all their power, imaging machines are like the Mars probe: they see surfaces, mountain peaks, valleys — without being able to take samples of the underlying terrain. The regions that peak in activity when a person is happy or guilty or jealous are connected to many other areas along complex circuits distributed throughout the brain that are, for the most part, still unlit by the computerized spotlight of the imaging machine. And it is here, in these subterranean, subtle enfoldings of the brain, that neuroscientists say they are most likely to discover its deepest secrets. "Any new method in neuroscience is powerful in terms of evolution of the field only insofar as it tells us that something we thought we knew is wrong," said Dr. J. Anthony Movshon, director of New York University's Center for Neural Science. So far, he said, brain imaging has not done that. The technology, he said, though now central to brain science, "is in one sense disappointing, in that so far it has told us nothing more than what a neurologist of the 19th century could have told you about brain functions and where they're localized."
     And that may be where the hazard lies. The brain's increasingly popular image is a fascinating prop, a colorful as well as useful map, but so far it provides only the illusion of depth. The subtle biology that integrates and coordinates disparate areas of the brain, like the visual, the verbal and the emotional — the interlocking symphonies of activity that make us individuals, that help determine what we do when jealous or inspired by a work of art — are absent, despite all the color-coding and exotic names for areas of the brain. "The risk is that seeing the neural activity allows people to take away or excuse responsibility for a behavior — to take away the individual person," said Dr. Brown of the Einstein School of Medicine. But she could not elaborate. A camera crew from CNN was due to arrive, to talk to her about the brain in love.



Ancient Divorce Laws' Modern Quandary
Michelle Boorstein, Washington Post- 2/5/2006

Sarah Rosenbloom is stuck in a marital netherworld. She and her husband divorced seven years ago in Maryland civil court. But she remains married under Jewish law because he has refused to give her a religious divorce document known in Hebrew as a get . She can't date, let alone remarry, without violating the tenets of her faith -- and the 44-year-old Orthodox Jew is not about to take that step. "I truly believe it would be a terrible thing if I acted like I had a get ," said Rosenbloom, an English teacher who lives in Baltimore. "Do I question my faith? Sure. Do I rail against God? Sure. I can always question, but I am not going to give up my Judaism, my religiosity."
      Her case illustrates a growing debate among Orthodox Jews and members of other faiths over whether ancient religious laws governing divorce need to be adapted to the modern era. Devout people of all faiths are seeking divorce in higher numbers, experts say, which is putting pressure on religious authorities to loosen restrictions.
     Rosenbloom's predicament would have been unusual in an earlier time. Although Jewish law bars a woman from getting a divorce without her husband's consent, she may bring her case to a religious court. The courts in the past could pressure a man who denied his wife a divorce by ordering Jews to boycott his business or barring him access to synagogue. But such methods are not as effective in an Orthodox Jewish community that has become much more dispersed. Rosenbloom's ex-husband, Sam, who said he is still upset at her after a bitter custody fight, simply ignored the summons from Baltimore's Jewish court and moved to Gaithersburg. He also disregarded a ruling from the same court holding him in contempt.
     Women in Rosenbloom's situation are called agunah in Hebrew, which means "chained woman." There are no official figures on the number of agunah, but the Organization for the Resolution of Agunot -- a New York-based group that organizes pickets in front of the houses and businesses of men who refuse to give their wives divorces -- said it has been involved in about 100 cases since it formed less than three years ago. There are thousands of such women in New York alone, according to group member Yehoshua Zev.
     Faced with these contemporary quagmires, some Jewish officials are bending and reinterpreting religious law in an effort to join divine purpose with modern mores. Several Jewish courts in recent years have annulled marriages in cases similar to the Rosenblooms', citing evidence that the marriage was fraudulent -- a misrepresentation by one of the spouses, for example. Many rabbis have criticized those rulings, however, and warned that women who remarry in such cases will be guilty of adultery. A growing number of Orthodox Jews are signing prenuptial agreements -- documents enforceable in U.S. civil courts -- that require both sides in any future divorce proceeding to use the religious court system and abide by its ruling.
     The Beth Din of America, the nation's largest Jewish court, handles more than 300 divorces a year, a number that has been rising steadily, said Rabbi Yona Reiss, the organization's president. Despite its name, the Beth Din of America has no more authority than such local courts as the Rabbinical Council of Greater Washington and the Bais Din in Baltimore. The decentralized judicial system has added to the lack of consensus on the issue.
     Among Muslims, the rules surrounding divorce vary widely according to interpretation of sharia -- Islamic law. In some parts of the world, only a man can end a marriage -- unless he has legally shared that right with his wife. In other places, a woman can bring the matter before a court. Islamic legal authorities have begun expanding the circumstances in which a court can hear a divorce as well as the legitimate grounds for divorce to include, for example, incompatibility.
     Divorce is forbidden among Catholics, though a marriage can be annulled if a church tribunal rules that it never existed -- if, for example, one party lacked the capacity to consent or it was never consummated. The Vatican issued a streamlined procedure last year for Catholics seeking an annulment. Among the changes was one that allows a church appeals court to uphold an annulment even if it disagrees with the initial tribunal on the reasons the marriage should be voided. Vatican officials emphasized that the changes were merely bureaucratic and that the grounds for annulments had not changed, although they said the number of annulments granted in the United States has gone from fewer than 350 in 1968 to tens of thousands in recent years.
     Southern Baptists launched their own debate about divorce in 2000 when Charles Stanley, past president of the Southern Baptist Convention and a popular television preacher, got divorced. Long-standing tradition in that denomination holds that men are disqualified from being pastors once they divorce, based on the biblical mandate that ministers be "blameless, the husband of one wife, vigilant, sober, of good behavior." But some questioned how to apply those words, and an official at Stanley's church in Atlanta said to loud applause that Stanley would stay in his position, his "personal pain" having validated his ability to minister.
     Debate over divorce has increased in the Orthodox Jewish community as efforts to help such women as Rosenbloom have escalated in recent years. In addition to the use of prenuptials and annulments, New York's legislature has passed laws that put Jewish men who won't grant a religious divorce at a disadvantage in their civil divorce. Maryland lawmakers introduced similar legislation unsuccessfully for four straight years in the late 1990s; opponents said it was an unconstitutional mixing of church and state. The Jewish Press, one of the nation's largest Jewish newspapers, each week runs the names of men who have divorce-related court orders against them in an effort to embarrass them. "The agunah problem is a very serious one. It is one aspect of a greater recognition of family problems that maybe we've been sweeping under the carpet," said Rabbi Irving Breitowitz, a University of Maryland law professor who wrote a book about agunah. "We are bound by the principles, but we can try to devise new mechanisms."
     Among the protests held by agunah advocates was one a week ago at Sam Rosenbloom's home in Gaithersburg. A dozen people came out in the rain and began, as usual, with a prayer from the book of Psalms, asking God to hear their plea. "Sam Rosenbloom, give your wife a get ," they chanted. The protests started two years ago and have occurred almost weekly for the past month.
     But is this what God intended? To Naomi Klass Mauer, an editor at the Jewish Press and a former agunah, the problem is not God or the law but human beings. "There is no way the intention would be that a woman should be held up," said Mauer, whose ex-husband withheld a get for four years. "But there are a lot of laws I don't fully understand the reason for, but I believe. I believe that the Torah is divine law. Whether or not I can understand everything with my finite ability -- it would be nice. But just because I can't doesn't mean that I am going to discount the law or pick and choose."
     Sarah Rosenbloom also said the experience has not shaken her faith. "Can people pervert the law? Yes, and that's what Sam is doing," she said. Sam Rosenbloom does not see it that way. He believes the Orthodox community took his wife's side because they felt he was not observant enough. Harsh, untrue things were said about him, he said, adding that when Sarah apologizes and tells "the truth," she will get her divorce. To him, that seems in line with God's intention. "It's not a matter of complying with the Jewish court or a Jewish thing at all. It's about me being devalued as a human being," said Rosenbloom, who was raised in the less strict Conservative Jewish denomination. "I personally look to religion as a moral compass. But I am an independent thinker."
     His ex-wife said she sees religion more as a rule book than a compass. "Look, I don't think it's supposed to be that we say, 'This is God's will,' and we just sit there. I think we are supposed to put forth our maximum effort," she said, noting that in addition to the protests in front of her ex-husband's house, several Maryland rabbis have told their congregants not to buy from an Internet site on which he sells religious goods. "And I pray. I pray a lot."



Looking for the Lie
Robin Marantz Henig, New York Times- 2/5/2006

When people hear that I'm writing an article about deception, they're quick to tell me how to catch a liar. Liars always look to the left, several friends say; liars always cover their mouths, says a man sitting next to me on a plane. Beliefs about how lying looks are plentiful and often contradictory: depending on whom you choose to believe, liars can be detected because they fidget a lot, hold very still, cross their legs, cross their arms, look up, look down, make eye contact or fail to make eye contact. Freud thought anyone could spot deception by paying close enough attention, since the liar, he wrote, "chatters with his finger-tips; betrayal oozes out of him at every pore." Nietzsche wrote that "the mouth may lie, but the face it makes nonetheless tells the truth."

This idea is still with us, the notion that liars are easy to spot. Just last month, Charles Bond, a psychologist at Texas Christian University, reported that among 2,520 adults surveyed in 63 countries, more than 70 percent believe that liars tend to avert their gazes. The majority also believe that liars squirm, stutter, touch or scratch themselves or tell longer stories than usual. The liar stereotype exists in just about every culture, Bond wrote, and its persistence "would be less puzzling if we had more reason to imagine that it was true." What is true, instead, is that there are as many ways to lie as there are liars; there's no such thing as a dead giveaway.

Most people think they're good at spotting liars, but studies show otherwise. A very small minority of people, probably fewer than 5 percent, seem to have some innate ability to sniff out deception with accuracy. But in general, even professional lie-catchers, like judges and customs officials, perform, when tested, at a level not much better than chance. In other words, even the experts would have been right almost as often if they had just flipped a coin.

In the middle of the war on terrorism, the federal government is not willing to settle for 50-50 odds. "Credibility assessment" is the new catch phrase, which emerged at about the same time as "red-level alert" and "homeland security." Unfortunately, most of the devices now available, like the polygraph, detect not the lie but anxiety about the lie. The polygraph measures physiological responses to stress, like increases in blood pressure, respiration rate and electrodermal skin response. So it can miss the most dangerous liars: the ones who don't care that they're lying, don't know that they're lying or have been trained to lie. It can also miss liars with nothing to lose if they're detected, the true believers willing to die for the cause.

Responding to federal research incentives, a handful of scientists are building a cognitive theory of deception to show what lying looks like — on a liar's face, in a liar's demeanor and, most important, in a liar's brain. The ultimate goal is a foolproof technology for deception detection: a brain signature of lying, something as visible and unambiguous as Pinocchio's nose.

Deception is a complex thing, evanescent and difficult to pin down; it's no accident that the poets describe it with diaphanous imagery like "tangled web" and "tissue of lies." But the federal push for a new device for credibility assessment leaves little room for complexity; the government is looking for a blunt instrument, a way to pick out black and white from among the duplicitous grays.

Nearly a century ago the modern polygraph started out as a machine in search of an application; it hung around for lack of anything better. But the polygraph has been mired in controversy for years, with no strong scientific theory to adequately explain why, or even whether, it works. If the premature introduction of a new machine is to be avoided this time around, the first step is to do something that was never done with the polygraph, to develop a theory of the neurobiology of deception. Two strands of scientific work are currently involved in this effort: brain mapping, which uses the 21st century's most sophisticated techniques for visualizing patterns of brain metabolism and electrical activity; and face reading, which uses tools that are positively prehistoric, the same two eyes used by our primate ancestors to spot a liar.

As these two strands, the ancient and the futuristic, contribute to a new generation of lie detectors, the challenge will be twofold: to resist pressure to introduce new technologies before they are adequately tested and to fight the overzealous use of these technologies in places where they do not belong — to keep inviolable that most private preserve of our ordinary lives, the place inside everyone's head where secrets reside. The English language has 112 words for deception, according to one count, each with a different shade of meaning: collusion, fakery, malingering, self-deception, confabulation, prevarication, exaggeration, denial. Lies can be verbal or nonverbal, kindhearted or self-serving, devious or baldfaced; they can be lies of omission or lies of commission; they can be lies that undermine national security or lies that make a child feel better. And each type might involve a unique neural pathway.

To develop a theory of deception requires parsing the subject into its most basic components so it can be studied one element at a time. That's what Daniel Langleben has been doing at the University of Pennsylvania. Langleben, a psychiatrist, started an experiment on deception in 2000 with a simple design: a spontaneous yes-no lie using a deck of playing cards. His research involved taking brain images with a functional-M.R.I. scanner, a contraption not much bigger than a kayak but weighing 10 tons. Unlike a traditional M.R.I., which provides a picture of the brain's anatomy, the functional M.R.I. shows the brain in action. It takes a reading, every two to three seconds, of how much oxygen is being used throughout the brain, and that information is superimposed on an anatomical brain map to determine which regions are most active while performing a particular task.

There's very little about being in a functional-M.R.I. scanner that is natural: you are flat on your back, absolutely still, with your head immobilized by pillows and straps. The scanner makes a dreadful din, which headphones barely muffle. If you're part of an experiment, you might be given a device with buttons to press for "yes" or "no" and another device with a single panic button. Not only is the physical setup unnatural, but in most deception studies the experimental design is unnatural, too. It is difficult to replicate the real-world conditions of lying — the relationship between liar and target, the urgency not to get caught — in a functional-M.R.I. lab, or in any other kind of lab. But as an early step in mapping the lying brain, such artificiality has to suffice.

In Langleben's first deception study at Penn, the subjects were told at the beginning of the experiment to lie about a particular playing card, the five of clubs. To be sure the card carried no emotional weight, Langleben screened out compulsive gamblers from the group. One at a time, the subjects lay motionless in the scanner, watched pictures of playing cards flash onto a screen and pressed a button indicating whether they had that card or not. When an image of a card they didn't have came up, the subjects, as they had been instructed, told the truth and pressed "no." But when an image of the five of clubs came up, they also pressed "no," even though the card was in their pockets. That is, whenever they saw the five of clubs, they lied.

According to Langleben, certain regions of the brain were more active on average when his 18 subjects were lying than when they were telling the truth. Lying was associated with increased activity in several areas of the cortex, including the anterior cingulate cortex and the superior frontal gyrus. "We didn't have a map of deception in the brain — we still don't — so we didn't know exactly what this meant," Langleben said. "But that wasn't the question we were asking at the time in any case. What we were asking with that first experiment was, 'Can the difference in brain activity between lie and truth be detected by functional M.R.I.?' Our study showed that it can." He said that the prefrontal cortex — the reasoning part of the brain — was generally more aroused during lying than during truth-telling, an indication that it took more cognitive work to lie.

Brain mappers are just beginning to figure out how different parts of the brain function. The function of one region found to be activated in the five-of-clubs experiment, the anterior cingulate cortex, is still the subject of some debate; it is thought, among other things, to help a person choose between two conflicting responses, which makes it a logical place to look for a signature of deception. This region is also activated during the Stroop task, in which a series of words are written in different colors and the subject must respond with what color the ink is, disregarding the word itself. This is harder than it sounds, at least when the written word is a color word that is different from the ink it is written in. If the word "red" is written in blue, for instance, a lot of people say "red" instead of "blue." Telling a spontaneous lie is similar to the Stroop task in that it involves holding two things in mind simultaneously — in this case, the truth and the lie — and making a choice about which one to apply.Langleben performed his card experiment again in 2003, with a few refinements, including giving his subjects the choice of two cards to lie about and whether to lie at all. This second study found activation in some of the same regions as the first, establishing a pattern of deception-related activity in particular parts of the cortex: one in the front, two on the sides and two in the back. The finding in the back, the parietal cortex, intrigued Langleben.

"At first I thought the parietal finding was a fluke," he said. The parietal cortex is usually activated during arousal of various kinds. It is also involved in the manifestation of thoughts as physical changes, like goose bumps that erupt when you're afraid, or sweating that increases when you lie. The connection to sweating interested Langleben, since sweating is also one of the polygraph's hallmark measurements. He looked at existing studies of this response, and in all of them he found activity that could be traced back to the parietal lobe. Until Langleben's observation of its connection to brain changes, the sweat response (which the polygraph measures with sensors on the palm or fingertips) had been thought to be a purely "downstream" change, a secondary effect caused not by the lie itself but by the consequences of lying: guilt, anxiety, fear or the excess positive emotion one researcher calls "duping delight." But Langleben's findings indicated that it might have a corollary "upstream," in the central nervous system. This meant that at least one polygraph measurement might have a signature right at the source of the lie, the brain itself.

So there it was: the first intimation of a Pinocchio response.

The parietal-cortex finding, while speculative, is "interesting to pay attention to because of its relationship to the polygraph," Langleben said. "In this way, we might not have to cancel the polygraph. We may be able to put it on firm neuroscience footing."

One Lie Zone or Many?
Over at Harvard, Stephen Kosslyn, a psychologist, was looking at the map Langleben was starting to build and found himself troubled by the connection between deception and the anterior cingulate cortex. "Yes, it lights up during spontaneous lying," Kosslyn said, but it also lights up during other tasks, like the Stroop task, that have nothing to do with deception. "So it couldn't be the lie zone is a huge, multidimensional space," he said, "in which every combination of things matters." Kosslyn began by thinking about the different dimensions, the various ways that lies differ from one another in terms of how they are produced. Is the lie about you, or about someone else? Is it about something you did yesterday or something your friend plans to do tomorrow? Do you feel strongly about the lie? Are there serious consequences to getting caught? Each type of lie might lead to activation of particular parts of the brain, since each type involves its own set of neural processes.

He decided to compare the brain tracings for lies that are spontaneous, like those in Langleben's study, with those that are rehearsed. A spontaneous lie comes when a mother asks her teenage son, "Did you do your math homework?" A rehearsed lie comes when she asks him, "Why are you coming home an hour past your curfew?" The question about the homework probably surprises him, and he has to lie on the fly. The question about the curfew was probably one he had been anticipating, and concocting an answer to, for most of the previous hour.

Kosslyn's working hypothesis was that different brain networks are used during spontaneous lying than are used during truth-telling or the telling of a memorized lie. Spontaneous lying requires the liar not only to generate the lie and keep the lie in mind but also to keep in mind what the truth is, to avoid revealing it by mistake. In contrast, Kosslyn said, a rehearsed lie requires only that an individual retrieve the lie from memory, since the work of establishing a credible lie has already been done.

To help his subjects generate meaningful lies to memorize, Kosslyn asked them to provide details about one notable work experience and one vacation experience. Then he helped them construct what he called an "alternative-reality scenario" about one of them. (The other experience he held in reserve as the basis for his subject's unrehearsed spontaneous lies.) If the experience was a vacation in Miami, for instance, Kosslyn changed it to San Diego; if the person had gone there to visit a sister, he changed it to a visit to Uncle Sol. Kosslyn had the participants practice the false scenario for a few hours, and then he put them into a scanner at Harvard's functional-M.R.I. facility. There were 10 subjects altogether, all in their 20's.As he predicted, Kosslyn found that as far as the brain was concerned, spontaneous and rehearsed lies were two different things. They both involved memory processing, but of different kinds of memories, which in turn activated different regions of the cortex: one part of the frontal lobe (involved in working memory) for the spontaneous lie; a different part in the right anterior frontal cortex (involved in retrieving episodic memory) for the lie that was rehearsed. That's not much of a map yet, but it is a cumulative movement toward a theory of deception: that lying involves different cognitive work than truth-telling and that it activates several regions in the cerebral cortex that are also activated during certain memory and thinking tasks.

Even as these small bits of data emerge through functional-M.R.I. imagery, however, Kosslyn remains skeptical about the brain-mapping enterprise as a whole. "If I'm right, and deception turns out to be not just one thing, we need to start pulling the bird apart by its joints and looking at the underlying systems involved," he said. A true understanding of deception requires a fuller knowledge of functions like memory, perception and visual imagery, he said, aspects of neuroscience investigations not directly related to deception at all.

In Kosslyn's view, brain mapping and lie detection are two different things. The first is an academic exercise that might reveal some basic information about how the brain works, not only during lying but also during other high-level tasks; it uses whatever technology is available in the sophisticated neurophysiology lab. The second is a real-world enterprise, best accomplished not necessarily by using elaborate instruments but by encouraging people "to use their two eyes and brains." Searching for a "lie zone" of the brain as a counterterrorism strategy, he said, is like trying to get to the moon by climbing a tree. It feels as if you're getting somewhere because you're moving higher and higher. But then you get to the top of the tree, and there's nowhere else to go, and the moon is still hundreds of thousands of miles away. Better to have stayed on the ground and really figured out the problem before setting off on a path that looks like progress but is really nothing more than motion. Better, in this case, to discover what deception looks like in the brain by breaking it down into progressively smaller elements, no matter how artificial the setup and how tedious the process, before introducing a lie-detection device that doesn't really get you where you want to go.

Your Brain Waves Know You're a Liar
Even the most enthusiastic brain mappers probably agree with one aspect of Kosslyn's skeptical analysis: a true brain map of lying is, at best, elusive. Part of the difficulty comes from the technology itself. In the world of brain mapping, a functional-M.R.I. scan paints a picture that is broad and, in its way, lumbering. It can indicate which region of the brain is active, but it can take a reading no more frequently than once every two seconds.

For a more refined picture of cognitive change from one instant to the next, scientists have turned to the electroencephalogram, which detects neural impulses on the scale of milliseconds. But while EEG's might be ideal to answer "when" questions about brain activity, they are not so good at answering questions about "where." Most EEG's use 10 or 12 electrodes attached by a tacky glue at scattered spots on the scalp, which record electrical impulses firing from the brain as a whole. They give little indication of which region is doing the firing.

That's why deception researchers use a refined version of the ordinary EEG, which increases the number of electrodes from 12 to 128. These 128 electrodes, each the size of a typewriter key, are studded around a stretchy mesh cap. Using the cap, investigators can trace where electrical impulses are coming from when a person lies.

The cap is unwieldy and uncomfortable — definitely not ready yet for the world outside the laboratory. Jennifer Vendemia, a psychologist at the University of South Carolina, has been using the cap since 2000, when she began studying deception by looking at a particular class of brain wave known as E.R.P., for event-related potential. The E.R.P. wave represents electrical activity in response to a stimulus, usually 300 or 400 milliseconds after the stimulus is shown. It can be a sign that high-level cognitive processes, like paying attention and retrieving memories, are taking place.Vendemia has studied deception and E.R.P. waves in 626 undergraduates. She outfits them with the electrode cap and a plastic barbershop cape, which is necessary because, in order to maintain an electrical circuit, each of the 128 electrodes has to be thoroughly soaked. The cap is sopping wet when she puts it on her subjects, and during the experiment Vendemia occasionally comes into the room with a squirter and soaks it down some more.

Vendemia presented her subjects with a series of true-false statements, like "The grass is green" and "A snake has 13 legs," which they were instructed to answer either truthfully or deceptively, depending on which color the statement was written in. The subjects took a longer time — up to 200 milliseconds longer, on average — to lie than to tell the truth. They revealed a change in certain E.R.P. waves while they were lying, especially in the regions of the brain that the functional-M.R.I. scanners also focused on as possible lie zones: the parietal and medial regions of the brain, along the top and middle of the head.

"E.R.P. has the advantage of being a little more portable, and substantially less expensive, than M.R.I.," Vendemia said. "But E.R.P. cannot do some of the things that functional M.R.I. can do. If you're trying to model the brain, you really need both techniques."

One thing E.R.P. might eventually be able to do is predict whether someone intends to lie — even before he or she has made a decision about it. This brings us into sci-fi territory, into the realm of mind reading. When Vendemia has a subject in an E.R.P. cap, she can detect the first brain-wave changes within 240 to 260 milliseconds after a true-false statement appears on a computer screen. But these changes are an indication of intention, not action; it can take 400 to 600 milliseconds for a person to decide whether to respond with "true" or "false." "With E.R.P., I've taken away your right to make a decision about your response," Vendemia said. "It's the ultimate invasion." If someone knows before you do what your brain is indicating as your intention, is there any room left, in that window of a few hundred milliseconds, for the exercise of free will? Or have you already been labeled a liar by your spontaneous brain waves, without your having a chance to override them and choose a different path?

Lies make secrets possible; they let us carve out a private territory that no one, not even those closest to us, can enter without our permission. Without lies, there can be no such sanctuary, no interior life that is completely and inviolably ours. Do we want to allow anyone, whether a government interrogator or a beloved spouse, unfettered access to that interior life?

How Lies Leak Into the Open
Even a practiced lie-catcher like Paul Ekman recognizes that lying is a matter of privacy. "I don't use my ability to spot lies in my personal life," said Ekman, emeritus professor of psychology at the University of California, San Francisco. If his wife or two grown children want to lie to him, he said, that's their business: "They haven't given me the right to call them on their lies."

In his book "Telling Lies," Ekman underscored this point. His Facial Action Coding System, a precise categorization of the 10,000 or so expressions that are created by various combinations of 43 independent muscles in the face, allows him to do the same kind of mind reading that Vendemia can do with her E.R.P. cap. Facial expressions are hard-wired into the brain, according to Ekman, and can erupt without an individual's awareness about 200 milliseconds after a stimulus. Much like E.R.P. waves, then, a facial expression can give away your feelings before you are even aware of them, before you have made a conscious decision about whether to lie about those feelings or not. "Detecting clues to deceit is a presumption," Ekman wrote. "It takes without permission, despite the other person's wishes."

But in many situations, it's important to know who's lying to you, whether the liar wants you to or not. And for those times, Ekman said, his system of lie detection can be taught to anyone, with an accuracy rate of more than 95 percent. His holistic perspective is almost the polar opposite of brain mappers like Langleben's and Vendemia's: instead of focusing on the liar's neurons, Ekman takes a long, hard look at the liar's face.The Facial Action Coding System is the key to Ekman's strategy. Basic emotions lead to characteristic facial expressions, which only a handful of really good liars manage to conceal. Part of lying is putting on a false face that's consistent with the lie. But even practiced liars, according to Ekman, may not always be able to control the "leakage" of their true feelings, which flit across the face in microexpressions that last less than half a second. These microexpressions indicate an incongruity between the liar's words and his emotions. "It doesn't mean he's lying necessarily," Ekman said. "It's what I call a 'hot spot,' a point of discontinuity that deserves investigation."

Ekman teaches police investigators, embassy officials and others how to spot liars, including how to read these microexpressions. He begins by showing photos of faces in apparently neutral poses. In each face, a microexpression appears for 40 milliseconds, and the trainee has to press a button to indicate which emotion was in that microexpression: fear, anger, surprise, happiness, sadness, contempt or disgust. When I took the pretest to measure my innate lie-detecting capabilities, I could see the microexpressions in about 70 percent of the examples. But after about 15 minutes of training, I improved. The training session let me stop the action if I missed a question, since Ekman's idea is that if you know what you're looking for — and the microexpressions, when frozen, are vivid and easy to name — you can spot them even when they flash by in an instant. In the post-training test, I scored an 86 percent.

In addition to microexpressions, Ekman said, certain aspects of a person's demeanor can indicate whether he is lying. Voice, hand movements, posture, speech patterns: when these vary from how the person usually speaks or gesticulates, or when they don't fit the situation, that's another hot spot to explore. Word choices often change with lying, too, with the speaker using "distancing language," like fewer first-person pronouns and more in the third person. Also common are what Ekman calls "verbal hedges," which liars might use to buy time as they figure out what they want to say. To illustrate a verbal hedge, Ekman pointed to one of the many cartoons he uses in his workshops: a shark standing in a courtroom, looking up at the judge and saying, "Define 'frenzy."'

Ekman enjoys using these insights to unmask the lies of public figures (though he has a rule that prohibits him from commenting on any elected official currently in office, no matter how tempting a target). At his home in the Oakland Hills, he has a videotape library of some of the most notable lies of recent history, and he showed me how to watch one when I visited last fall. It was from a presidential news conference in early 1998, during the first days of the Monica Lewinsky scandal. Ekman smiled as he watched it; he knows this clip well. "I want you to listen to me," President Bill Clintonwas saying, shaking his forefinger like a schoolmarm. "I did not have sexual relations with that woman."

There it was: the president's "distancing language," calling Lewinsky "that woman," and an almost imperceptible softening of his voice at the end of the sentence. When this news conference was originally broadcast, Ekman said, "everyone I had ever trained from all over the country called me and said: 'Did you see the president? He's lying."'

Even though Ekman has been hired to teach his technique to embassy workers and military intelligence officers — to the tune of $35,000 for a five-day workshop — his low-tech approach to lie-catching is definitely out of vogue. "After 9/11," he said, "I contacted different federal agencies — the Defense Department, the C.I.A. — and said, 'I think there are some things I can teach your agents that can be of help right now."' But several turned him down, he said, with one person bluntly stating, "I can't support anything unless it ends in a machine doing it."

The First, Flawed Machine
The quest for such a machine has roots in the early 20th century, when the first modern lie detector, a rudimentary polygraph, was introduced. The man often cited as its inventor, William Moulton Marston, was a Harvard-trained psychologist who went on to make his mark as the creator of the comic-book character Wonder Woman. Not coincidentally, one of Wonder Woman's most potent weapons was her Magic Lasso, which made it impossible for anyone in its grip to tell a lie.

Marston spent 20 years trying to get his machine used by the military, in courts and even in advertising. After the success of Wonder Woman, however, he used it mostly for entertainment. His comic-book editor, Sheldon Mayer, recalled being hooked up to a polygraph during a party at Marston's home. After a few warm-up questions, Marston tossed him a zinger, "Do you think you're the greatest cartoonist in the world?" As Mayer wrote in his memoir, "I felt I was being quite truthful when I said no, and it turned out I was lying!" What an interesting reaction — even if, as was likely, Mayer was just trying to be funny. Because how prescient, really, to joke that the machine must have been right, that the machine knew more about Mayer than he did himself. It's the power of a simple mechanical device to make you doubt your own concept of truth and lie — "It turned out I was lying" — that made the polygraph so alluring, and so disturbing. And it's that power, combined with the idea that the machines are peering directly into the brain, that makes the

Today, the polygraph is the subject of much controversy, with organizations devoted to publicizing "countermeasures" — ways to subvert the results — to prove how unreliable it is. But the American Polygraph Association says it has "great probative value," and police departments still use it to help focus their criminal investigations and to try to extract confessions. The polygraph is also used to screen potential and current federal employees in law enforcement and for security clearances, although private employers are prohibited from using it as a pre-employment screen. Polygraphists are also routinely brought in to investigate such matters as insurance fraud, corporate theft and contested divorce.

But there is little scientific evidence to back up the accuracy of the polygraph. "There has been no serious effort in the U.S. government to develop the scientific basis for the psychophysiological detection of deception by any technique," stated a report issued by the National Research Council in 2003. Polygraph research has been "managed and supported by national security and law enforcement agencies that do not operate in a culture of science," the council said, suggesting that these are not the best settings for an objective assessment of any device's pros and cons.

The polygraph has many cons. It requires a suspect who is cooperative, feels guilty or anxious about lying and hasn't been educated to the various countermeasures that can thwart the results. Polygraph results can be more reliable in investigations in which the questioners already know what they're looking for. This allows investigators to develop a line of questioning that leads to something like the Guilty Knowledge Test. This is a multiple-choice test in which the answer is something only a guilty person would know — and only a guilty person's polygraph readings would indicate arousal upon hearing it.

The history of polygraphs is a cautionary tale, an example of how not to introduce the next generation of credibility-assessment devices. "Security and law enforcement agencies need to improve their capability to independently evaluate claims proffered by advocates of new techniques for detecting deception," the National Research Council said. "The history of the polygraph makes clear that such agencies typically let clinical judgment outweigh scientific evidence."

Thermal Scanners, Eye Trackers and Pupillometers
History is in some danger of repeating itself at the site of the government's most focused effort to look for the next generation of lie detectors, the Department of Defense Polygraph Institute. This is where the brain mapping of the academic investigators is turned into practical machinery. Scientists at Dodpi (pronounced DOD-pie) are an inventive bunch, investigating instruments that measure the body's emission of heat, light, vibration or any other physiological properties that might change when someone tells a lie.

The Dodpi facility sits at one end of the huge Army base at Fort Jackson, S.C., where Army recruits en route to Iraq go for basic training. Among the new machines being studied is a thermal scanner, in which a computer image of a person's face is color-coded according to how much heat it emits. The region of interest, just inside each eye, grows hotter when a person lies. It also grows hotter during many other cognitive tasks, however, so a more specific signature for deception might be required to keep the thermal scanner from falling prey to the same problems of imprecision as the polygraph.Another machine is the eye tracker, which follows a person's gaze — its fixation, duration, rapid eye movements and scanning path — to determine if he's looking at something he has seen before. It can be thought of as a mute version of the Guilty Knowledge Test.

Other high-tech deception detectors — many of them capable of remote operation, so they could theoretically be used without a suspect's knowledge — are being developed at laboratories across the country, with financing from agencies like Dodpi, the Department of Homeland Security and the Defense Advanced Research Projects Agency. (Defense Department officials will not reveal the amount they spend on credibility assessment, nor the degree to which the budget has increased since 9/11, because some of the research is classified.) The detectors look for increases in physiological processes that are associated with lying: a sniffer test that measures levels of stress hormones on the breath, for instance, a pupillometer that measures pupil dilation and a near-infrared-light beam that measures blood flow to the cerebral cortex.

With this push for an automated lie detector, some observers worry that we'll see a replay of the polygraph experience: the marketing of a halfway technology not quite capable of separating lying from other cognitive or emotional tasks. The polygraph was a machine in search of an application, and it became entrenched in criminal justice more out of habit than out of proved efficacy. This could easily happen again, as credibility assessment is being lauded as a crucial counterterrorism tool.

"The fear is that because so much money has been put into homeland security, that people may be trying to find quick solutions to complex problems by buying something," said Tom Zeffiro, a neurologist at Georgetown University and chairman of a workshop on high-tech credibility assessment sponsored last summer by the National Science Foundation. "And technology that might not be thoroughly evaluated might be put into practice." Already there are efforts to sell computer algorithms and devices that some scientists believe to be insufficiently tested, products with names like Brain Fingerprinting and No Lie M.R.I. Zeffiro said that one of his workshop suggestions is to establish a neutral testing laboratory to keep such products from being used commercially before there is at least some minimum amount of evidence that they work.

Big Brother concerns hover in the background, too, with some of these instruments, especially the smallest ones. It is sobering to think that we might be moving toward a society in which hidden sensors are trying, in one way or another, to read our minds. At Dodpi, however, scientists don't seem to fret much about such things. "The operational use of what we develop is not something we think about," said Andrew Ryan, a former police psychologist who is the head of research at Dodpi. "Our job is to develop the science. Once that science is developed, how it's used is up to other people."

The Smudge of Ordinary Lies
Each day we walk a fine line between deception and discretion. "Everybody lies," Mark Twain wrote, "every day; every hour; awake; asleep; in his dreams; in his joy; in his mourning."

First there are the lies of omission. You go out to dinner with your sister and her handsome new boyfriend, and you find him obnoxious. When you and your sister discuss the evening later, isn't it a lie for you to talk about the restaurant and not about the boyfriend? What if you talk about his good looks and not about his offensive personality?

Then there are the lies of commission, many of which are harmless, the lies that allow us to get along with one another. When you receive a gift you can't use, or are invited to lunch with a co-worker you dislike, you're likely to say, "Thank you, it's perfect" or "I wish I could, but I have a dentist's appointment," rather than speak the harsher truth. These are the lies we teach our children to tell; we call them manners. Even our automatic response of "Fine" to a neighbor's equally automatic "How are you?" is often, when you get right down to it, a lie.

More serious lies can have a range of motives and implications. They can be malicious, like lying about a rival's behavior in order to get him fired, or merely strategic, like not telling your wife about your mistress. Not every one of them is a lie that needs to be uncovered. "We humans are active, creative mammals who can represent what exists as if it did not, and what doesn't exist as if it did," wrote David Nyberg, a visiting scholar at Bowdoin College, in "The Varnished Truth." "Concealment, obliqueness, silence, outright lying — all help to hold Nemesis at bay; all help us abide too-large helpings of reality." Learning to lie is an important part of maturation. What makes a child able to start telling lies, usually at about age 3 or 4, is that he has begun developing a theory of mind, the idea that what goes on in his head is different from what goes on in other people's heads. With his first lie to his mother, the power balance shifts imperceptibly: he now knows something she doesn't know. With each new lie, he gains a bit more power over the person who believes him. After a while, the ability to lie becomes just another part of his emotional landscape.

"Lying is just so ordinary, so much a part of our everyday lives and everyday conversations," that we hardly notice it, said Bella DePaulo, a psychologist at the University of California, Santa Barbara. "And in many cases it would be more difficult, challenging and stressful for people to tell the truth than to lie."

In the 1990's, DePaulo asked 147 people to keep a diary of their social interactions for one week and to note "any time you intentionally try to mislead someone," either verbally or nonverbally. At the end of the week, the subjects had lied, on average, 1.5 times a day. "Lied about where I had been," read a diary entry. "Said that I did not have change for a dollar." "Told him I had done poorly on my calculus homework when I had aced it." "Said I had been true to my girl."

People didn't feel guilty about these lies, by and large, but lying still left them with what DePaulo called a "smudge," a sort of smarmy feeling after lying. Her subjects reported feeling less positive about their interactions with people to whom they had lied than to people to whom they had not lied.

Still, DePaulo said that her research led her to believe that not all lying is bad, that it often serves a perfectly respectable purpose; in fact, it is sometimes a nobler, or at least kinder, option than telling the truth. "I call them kindhearted lies, the lies you tell to protect someone else's life or feelings," DePaulo said. A kindhearted lie is when a genetic counselor says nothing when she happens to find out, during a straightforward test for birth defects, that a man could not possibly have fathered his wife's new baby. It's when a neighbor lies about hiding a Jewish family in Nazi-occupied Poland. It's when a doctor tells a terminally ill patient that the new might work. And it's when a mother tells her daughter that nothing bad will ever happen to her.

"We found in our studies that these were the lies that women most often told to other women," DePaulo said. "Women are the ones saying, 'You did the right thing,' 'I know just how you feel,' 'That was a lovely dinner,' 'You look great.' I don't think they're doing that because they think the truth is unimportant or because they have a casual attitude toward lying. I think they just value their friends' feelings more than they value the truth."

If the search for an all-purpose lie detector were successful, and these everyday lies were uncovered along with the threatening or malicious ones, we might, paradoxically, end up feeling a little less safe than we felt before. It would be destabilizing indeed to be stripped of the half-truths and delusions on which social life depends.

Does Lying Make Us Smarter?
Personally, I cannot tell a lie. This is not to say that I never lie; I'm just not very good at it. My lies are mostly lies of omission, secrets that I choose not to talk about at all, because when I do say something deceptive, people usually see right through me.

I realize that my honesty comes as much from ineptitude as from integrity. In fact, my own dirty little secret is that I wish I were a better liar; I think it would make me a more interesting person, maybe even a better writer. Still, when I told Paul Ekman that I hardly ever lie, I detected in my voice an unseemly amount of pride.

Ekman's response surprised me. He is, after all, one of the nation's leading experts on spotting liars; I expected him to nod sagely, approving of me and my truthful ways. Instead, he listened to my veiled boast with a patient little smile. Then, without missing a beat, he started enumerating the qualities that are required to lie. To lie, he told me, a person needs three things: to be able to think strategically and plan her moves ahead of time, like a good chess player; to read the needs of other people and put herself in their shoes, like a good therapist; and to manage her emotions, like a grown-up person.

So had this very nice, polite, accomplished man dissed me? Had Ekman told me, indirectly, that bad liars like me are immature, unempathetic and not especially bright? Had he pointed out that the skills of lying are the same skills involved in the best human social interactions?Probably. (Would he tell me the truth if I asked him?) Deception is, after all, one trait associated with the evolution of higher intelligence. According to the Machiavellian Intelligence Hypothesis, developed by Richard Byrne and Andrew Whiten, two Scottish primatologists at the University of St. Andrews in Fife, the more social a species, the more intelligent it is. The hypothesis holds that as social interactions became more and more complex, our primate ancestors evolved so they could engage in the trickery, manipulation, skulduggery and sleight of hand needed to live in large social groups, which helped

"All of a sudden, the idea that intelligence began in social manipulation, deceit and cunning cooperation seems to explain everything we had always puzzled about," Byrne and Whiten wrote. In 2004, Byrne and another colleague, Nadia Corp, looked at the brains and behavior of 18 primate species and found empirical support for the hypothesis: the bigger the neocortex, the more deceptive the behavior.

But even if liars are smarter and more successful than the rest of us, most people I know seem to be like me: secretly smug about their honesty, rarely admitting to telling lies. One notable exception is a friend who blurted out, when she heard I was writing this article, "I lie all the time."

Lying started early for this friend, she wrote later in an e-mail message. She grew up in a big, competitive family (14 siblings and step-siblings in all), and lying was the easiest way to get a word in edgewise. "There were so many of us," she wrote, "asserting knowledge became even more prized than the knowledge itself — because you were heard." If she didn't know something, she made it up. It got her siblings' attention.

These days, my friend, who is a novelist, claims that she lies almost reflexively. Maybe it gives her power to have information she's not sharing with her loved ones, she wrote; maybe it's just something left over from her childhood struggle for attention and from her writerly need to flex her imagination. "If I'm on the phone and my husband walks in and says, 'Who's that?' I might say Jill if it's Joan," she wrote to me. "Or if my mother asks me who I had lunch with, I'll tell her Caroline when it was Alice, for no good reason. This kind of useless lying is harmless except when I get caught — and I do get caught, because keeping track of useless lies is both daunting and exhausting."

My friend might be aware of getting caught, but habitual liars like her are probably harder to spot than neophytes like me. People who lie a lot are good at it, and they don't worry as much as I do about getting caught. And no matter what device or technique of lie detection is used, the liar who doesn't strain at her deception is still less likely to be fingered than the liar who does.

In a recent study looking at the brain anatomy of pathological liars versus nonliars, researchers at the University of Southern California found that the liars had more white matter in their prefrontal cortexes. The investigators found their subjects partly through self-identification, an odd choice in a study of pathological liars. But it was an intriguing finding nonetheless. "White matter is pivotal to the connectivity and cognitive function of the human brain," Sean Spence, a deception researcher and psychiatrist at the University of Sheffield, wrote in an editorial accompanying the study's publication in the British Journal of Psychiatry last October. "And abnormal prefrontal white matter might affect complex behaviors such as deception."

As for my lying friend, she may or may not have an excess of white matter in the front of her brain. But she does lie, often. Her lies have no hidden purpose, she told me; she lies only for the sake of lying. "Of course," she added in her e-mail message, "I could be lying about all of this."

Today's federal effort to develop an efficient machine for credibility assessment has been compared to the Manhattan Project, the secret government undertaking to build the atomic bomb. This sounds hyperbolic, to compare a high-tech lie detector to a weapon of mass destruction, but Tom Zeffiro, who made the analogy, said that they raise similar moral quandaries, especially for the scientists doing the research. If a truly efficient lie detector could be developed, he said, we might find ourselves living in "a fundamentally different world than the one we live in today."

In the quest to make the country safer by looking for brain tracings of lies, it might turn out to be all but impossible to tell which tracings are signatures of truly dangerous lies and which are the images of lies that are harmless and kindhearted, or self-serving without being dangerous. As a result, we might find ourselves with instruments that can detect deception not only as an antiterrorism device but also in situations that have little to do with national security: job interviews, tax audits, classrooms, boardrooms, courtrooms, bedrooms.

This would be a problem. As the great physician-essayist Lewis Thomas once wrote, a foolproof lie-detection device would turn our quotidian lives upside down: "Before long, we would stop speaking to each other, television would be abolished as a habitual felon, politicians would be confined by house arrest and civilization would come to a standstill." It would be a mistake to bring such a device too rapidly to market, before considering what might happen not only if it didn't work — which is the kind of risk we're accustomed to thinking about — but also what might happen if it did. Worse than living in a world plagued by uncertainty, in which we can never know for sure who is lying to whom, might be to live in a world plagued by its opposite: certainty about where the lies are, thus forcing us to tell one another nothing but the truth.


Study: Combat Trauma Seen in Civil War
Associated Press, 2/6/2006

CHICAGO -- A look at the medical records of Civil War soldiers suggests post-traumatic stress disorder existed back then, too, according to a study.

The researchers found that veterans who saw more death in battle had higher rates of postwar illness. Younger soldiers, including boys as young as 9, were more likely than older ones to suffer mental and physical problems after the war.

''Increased war trauma leads to increased physical and mental illness,'' said study co-author Roxane Cohen Silver of the University of California at Irvine. ''That message can be applied to wars around the globe.''

The findings, published in the February issue of Archives of General Psychiatry, were drawn from pension records on more than 15,000 Union Army veterans. The researchers examined the records, which included doctors' reports of illnesses, to find signs of cardiac, gastrointestinal and mental health problems.

Warring soldiers have carried home psychological scars for centuries. In American wars, the phenomenon has been called shell shock, combat fatigue and post-Vietnam syndrome. Medical authorities first accepted PTSD as a distinct psychiatric condition in 1980 at the urging of Vietnam veterans and their doctors.

In an editorial accompanying the new study, Dr. Roger Pitman of Harvard Medical School said the findings ''should lay to rest the notion that there was something psychiatrically unique about the Vietnam Conflict or about what used to be called `post-Vietnam syndrome.'''

In PTSD, stress hormones like adrenaline scorch a painful event deep into long-term memory, scientists believe. People get edgy, fearful and prone to nightmares or flashbacks.

The study relied on a database managed by the University of Chicago.

Eric T. Dean, author of ''Shook over Hell: Post-Traumatic Stress, Vietnam, and the Civil War,'' used the same records in his research. He said he is skeptical the 19th-century medical records could be made standard enough for the researchers' statistical analysis to be valid.

He also questioned relying on the diagnoses of doctors from the 1800s.

''This is a heroic effort,'' Dean said. ''I just think it's a stretch. Beyond proving war is hell, I just question their nuanced conclusions.''

On the Net:

Archives of General Psychiatry: http://www.archgenpsychiatry.com


Mental Health Care Limited for Immigrants
Associated Press, 2/6/2006

DE QUEEN, Ark. -- If Eleazar Paula Mendez suffered from depression, her adopted hometown in southwest Arkansas was not the place to find help: The small community where she is charged with killing her three children has no mental-health professionals who speak Spanish.

Mendez, who told police she was distraught because her husband wanted a divorce, sought spiritual counseling from her priest, but he also did not know where she could get psychological help.

''Her English is very limited,'' the Rev. Salvador Marquez-Munoz said. ''And who am I going to refer her to around here?''

Arkansas had the second-fastest growing Hispanic population in the 1990s, according to Census figures, but many communities have limited social services catering to them.

In De Queen -- which is 50 percent Hispanic -- the largest mental-health clinic relies on an interpreter.

''I think it would be helpful to be able to communicate a little bit better,'' said Michael J. Cluts, director of the Southwest Arkansas Counseling and Mental Health Center.

The town's only private counselor, social worker Daryl Mitchell, has occasionally helped Spanish-speakers who brought a trusted adult to translate.

Depression can affect many Hispanics because of separation from loved ones back home, financial problems and cultural barriers, said Cesar Compadre, who heads La Casa Health Network, a Little Rock-based organization that connects Hispanics with health care resources.

''The way I see it, talking to people, there is an epidemic of depression among the Latino community,'' he said. ''You almost feel it.''

The situation is compounded by the lack of Spanish-speaking mental-health workers in Arkansas, he said.

''We have had people come into La Casa and say 'You know, I need help, I feel that I want to hurt my kids,''' he said.

Some immigrants may be nervous about talking about their problems to an outsider if they entered the country illegally, said the priest, Marquez-Munoz. And emotions and nuances are lost in translation.

''It's like trying to watch a movie that has been dubbed,'' Marquez-Munoz said.

John Shuler, a social worker with Ozark Guidance mental-health group in northwestern Arkansas, said his program has seen improvement after hiring Spanish-speaking counselors last year to work with school children and their parents.

''Whenever you have an interpreter, because you're not speaking directly with the individual, with the client, it can impact the relationship, the therapeutic relationship in a negative way,'' Shuler said.

In De Queen, a judge has ordered a mental evaluation for Mendez, who is charged with capital murder in the deaths of Elvis, 7, and twins Samantha and Samuel, 5.

The Mexican-born Mendez had lived in the United States about 11 years and last year moved from New York City to Arkansas to raise her children in a safer environment, neighbors said. She was reserved and had few friends, said an acquaintance, M. Rocio Maya.

Police say Mendez, 43, became distraught when her husband, who was working in New York, asked for a divorce. Maya also said he had begun sending her less money.

But her husband, Arturo Morales, said his marriage was good.

''She was probably suffering loneliness due to the physical separation in the last months,'' Morales said.

Marquez-Munoz, a priest at St. Barbara Catholic Church, said Mendez met with him to speak about her problems in November or December and again about a week before the children were killed.

''Regarding spiritual counseling, I can help with that, but psychological counseling to a profound level, I cannot,'' the priest said.

Marquez-Munoz said he'd be interested in working more closely with mental-health professionals and doctors -- people ''who can help heal the many wounds people are carrying, their crosses.''

The priest, who is also from Mexico, said he could not discuss what Mendez had told him.

''She did not share with me everything she was dealing with, you know,'' he said. ''It takes time. And she ran out of time.''


Why the Aging Mind Is Driven to Distraction
Robert Lee Hotz, Los Angeles Times- 2/6/2006

NEW YORK — Exploring the anatomy of attention, researchers have discovered that middle-aged people are more readily driven to distraction by interruptions because of age-related changes in how their brains work.

In research made public today, scientists at the University of Toronto and the Rotman Research Institute documented for the first time how age altered the brain's ability to ignore irrelevant intrusions.

"I have certainly found that as I have gotten older it is harder to deal with distractions," said lead author Cheryl L. Grady, 52, who studies the cognitive effects of aging. "This experiment tells me why that is. This is happening in my brain."

By scanning the brains of healthy young, middle-aged and elderly people, Grady and her colleagues detected a gradual breakdown in the brain circuits that maintain the normal balance of the attention span.

Two key regions of the brain that allow the mind to focus on a single task and tune out unwanted thoughts get out of kilter much earlier in life than previously suspected.

Normally, special neural circuits in the prefrontal cortex become more active when the mind pays strict attention.

At the same time, related brain areas in the medial frontal lobe — thought to monitor more general background activity — simultaneously slack off.

When the mind is at rest, the level of brain activity in those regions is then supposed to reverse.

The researchers discovered, however, that starting at about age 40, this seesaw pattern began to break down during memory tasks.

"It's known that older adults are more easily distracted. We think we've found a mechanism in the brain to explain this," Grady said. "The functional changes are detectable by middle age."

The study, funded by the Canadian Institutes of Health Research, is published in the Journal of Cognitive Neuroscience.

As a practical matter, many researchers are trying to learn whether multi-tasking techniques meant to improve communication and productivity could instead make people scatterbrained, leaving them lethargic and forgetful.

By one published estimate, the typical office worker is interrupted every three minutes.

Scientists from King's College at the University of London, for example, recently determined that people trying to juggle phone calls, e-mail and other routine office distractions suffered a greater loss of IQ than someone smoking marijuana.

Grady, however, suggested that people in their 20s today — their brains molded by instant messaging and all of the other high-technology of the short attention span — may be better able to manage unwarranted interruptions when they reach old age.

"If you are a 20-year-old today," Grady said, "you may find it easier to deal with distraction when you are 60 because you have had so much practice."


Stability of Mentally Ill Shaken By Medicare Drug Plan Problems
Susan Levine, Washington Post- 2/6/2006

Even among the incident reports crossing Craig Knoll's desk weekly now, this one stood out: A 43-year-old client of Knoll's mental health agency, a man who suffers from bipolar disorder, had come from his pharmacy frustrated to the point of meltdown. There were snags in his new Medicare drug plan. Of his four medicines, it would fill only two.

"I'm not going to take any of them anymore," he yelled, according to the report by caseworkers. Before they could do anything, he grabbed the prescription bottles he'd just gotten, ran for the restroom and dumped both in the toilet.

"He flushed everything he had on hand," recounted Knoll, executive director of Threshold Services in Silver Spring, whose staff spent day after day last month grappling with the many ramifications of the government's troubled program. Threshold came to the rescue of clients who couldn't get any medications or who, despite their pills, were in increasing distress because of all the confusion. It reimbursed several who'd mistakenly paid hundreds of dollars for pills that should have cost them a few dollars -- and replenished the supply of the client who had thrown his away.

"I'm not saying it's the federal government's fault he flushed his meds," Knoll said. "I'm saying it's the federal government's fault he couldn't get his meds. It's not surprising that people with mental illness respond in ways that people with mental illness respond."

Since the prescription program made its debut Jan. 1, some of the estimated 2 million mentally ill Americans covered because they receive both Medicare and Medicaid have gone without the drugs that keep their delusions, paranoia, anxieties or stress in check. Mental health service providers and advocacy organizations nationwide say they worry that scores are at high risk of relapse. Numerous people have been hospitalized.

"The continuation of medications is absolutely critical to keep them in community living," said Steven S. Sharfstein, chief executive of the Shepherd-Pratt Health System in Baltimore and president of the American Psychiatric Association. Last week, the association joined other mental health groups in a lengthy talk with Medicare officials about the myriad problems.

"I really don't know what the future will bring. . . . I have a very deep concern that psychiatric patients will suffer disproportionately," Sharfstein said. "If by the end of February or March, if [federal officials] haven't figured this out, we could have an epidemic on our hands."

The mentally ill are nearly a third of the "dual eligibles" who qualify for both Medicare and Medicaid because of income and disability or age. Mark B. McClellan, head of the Centers for Medicare and Medicaid Services, told a Senate committee hearing Thursday that a prime focus is resolving the "remaining transition issues" for this extremely vulnerable population.

That will not happen quickly. Like other Medicare-Medicaid recipients, the mentally ill were to have been signed up automatically for Part D at the start of the year, with responsibility for their prescriptions shifted seamlessly to private drug plans. Clinicians expected a bumpy beginning even in the best of circumstances. The new coverage often forces beneficiaries to switch from their usual pharmacies to different locations and strange faces, changes that Pam Cudahy of St. Luke's House in Bethesda said can have a huge effect on someone with few coping resources.

"Is the environment familiar? Is the person [behind the counter] familiar? When I show my prescription card, will the same thing happen as happened before?" Such questions represent daunting challenges, explained Cudahy, whose agency provides crisis care and psychiatric rehabilitation to about 1,000 teenagers and adults. "You don't want something to happen they're not expecting."

But repeatedly, she and others say, people have fallen through the program's cracks and discovered they have no insurance -- and have either run out of pills or rationed their medicine because they feared they would be left without.

Or they have been assigned to plans that will pay for some but not all of their psychiatric prescriptions -- an untenable and potentially dangerous situation given the complicated multiplicity of drugs people often take, with some pills to treat symptoms and others to counteract side effects. Unlike many medicines, psychiatric drugs are not easily substituted.

In Alexandria last month, a mother of two with a history of homelessness and attempted suicide left a drugstore empty-handed after being told her antidepressant was not covered. "For her, it was overwhelming," said Lix Wixson, director of acute care at the local Community Services Board. "She shut down."

The agency bought her a week's supply of Lexapro while it changed her plan and stabilized her condition. In fact, it made repeated purchases for clients in January at a cost exceeding $2,400. That's money unlikely to be reimbursed. "We can't do that indefinitely," Wixson said.

St. Luke's House turned to Montgomery County's mental health prescription contract for assistance. At one point, the organization was counseling 15 people with disabling illnesses, Part D errors and dwindling prescriptions. Michelle Ponder of Rockville was among them, and she admits she was scared as she counted down her pills. Her daily dosage includes Lamictal, a finely tuned mood stabilizer; Seroquel, which is used for schizophrenia or bipolar disorder; and Lithobid, a controlled form of lithium. Together, the three keep her out of the hospital, she believes.

Her housemate, Geraldine Champa, came close, too. More than a week into 2006, she was down to only two of the orange tablets that minimize the extreme mood swings and panic attacks that otherwise derail her life. With medication, she can manage much like the next person, with a part-time job and her own independence. Without it, she starts to lose control. The upset returns, and the anger. She has more and more difficulty dealing with others.

"You can't skip a day," she explained recently, as Ponder and several others at St. Luke's nodded their understanding.

Yet even months of well-informed guidance and planning are no guarantee. "It still crumbles in front of you," said a tired Cherie Sammis, clinical director of the Perry Family Health Center in Northwest, although the calls that have been waking her at 5:30 a.m., interrupting her at work and continuing late into the night have come not from center patients but from family halfway across the country.

Sammis's younger sister struggles with manic depression and schizophrenia. As her fears about her Medicare prescription coverage spiraled -- fears borne out by repeated computer glitches and plan inconsistencies -- she deteriorated precipitously. Recently, she told Sammis long-distance: " 'I've hurt myself before. . . . I'll hurt myself again. I've got to save my life.' "